Document Detail


In view of an optimal gut antifungal therapeutic strategy: an in vitro susceptibility and toxicity study testing a novel phyto-compound.
MedLine Citation:
PMID:  15904429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In view of the raising concern for gut fungal infection, the aim of the present research was to carry out a systematic in vitro study testing the antifungal activity and possible toxicity of a polygodyal-anethole compound (Kolorex) in several strains of Candida albicans and in other fungal pathogens. METHODS: The in vitro susceptibility tests were carried out on 4 strains of C. albicans (C. krusei, C. lipolytica, C. tropicalis, C. utilis), Aspergillus flavus and A. fumigatus. Cultures were also analyzed by varying medium, pH and inoculum size, and a time-course killing test was carried out. RESULTS: In the present study the polygodyal-anethole compound showed remarkable in vitro activity against the most common fungi, which was significantly better than polygodyal alone. Moreover, such mixture compound was shown to exert its activity against a wide spectrum of fungi, including C. lipolytica and C. tropicalis, which required significantly higher MIC of polygodyal to be unfeasible in clinical application. The activity of the polygodyal-anethole compound was significantly better than polygodyal alone with high inoculum size and low pH. Moreover, it proved to exert a significantly faster biological activity against low inoculum. CONCLUSIONS: This study suggests that the mixture compound Kolorex has a very good profile of antifungal activity in terms of effectiveness and spectrum of action while being devoid of any significant toxicity.
Authors:
Yussef Metugriachuk; Olivia Kuroi; Kanok Pavasuthipaisit; Junji Tsuchiya; Emilio Minelli; Ruichi Okura; Edoardo Fesce; F Marotta
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Chinese journal of digestive diseases     Volume:  6     ISSN:  1443-9611     ISO Abbreviation:  Chin J Dig Dis     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-20     Completed Date:  2005-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101088612     Medline TA:  Chin J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
Affiliation:
TMC Hospital, Shizuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anisoles
Antifungal Agents / pharmacology*,  toxicity
Aspergillus flavus / drug effects
Aspergillus fumigatus / drug effects
Candida albicans / drug effects
Candida tropicalis / drug effects
Fungi / drug effects*
Intestines / microbiology*
Microbial Sensitivity Tests*
Rats
Sesquiterpenes / pharmacology*,  toxicity
Chemical
Reg. No./Substance:
0/Anisoles; 0/Antifungal Agents; 0/Sesquiterpenes; 104-46-1/anethole; 6754-20-7/polygodial

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