| In view of an optimal gut antifungal therapeutic strategy: an in vitro susceptibility and toxicity study testing a novel phyto-compound. | |
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MedLine Citation:
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PMID: 15904429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In view of the raising concern for gut fungal infection, the aim of the present research was to carry out a systematic in vitro study testing the antifungal activity and possible toxicity of a polygodyal-anethole compound (Kolorex) in several strains of Candida albicans and in other fungal pathogens. METHODS: The in vitro susceptibility tests were carried out on 4 strains of C. albicans (C. krusei, C. lipolytica, C. tropicalis, C. utilis), Aspergillus flavus and A. fumigatus. Cultures were also analyzed by varying medium, pH and inoculum size, and a time-course killing test was carried out. RESULTS: In the present study the polygodyal-anethole compound showed remarkable in vitro activity against the most common fungi, which was significantly better than polygodyal alone. Moreover, such mixture compound was shown to exert its activity against a wide spectrum of fungi, including C. lipolytica and C. tropicalis, which required significantly higher MIC of polygodyal to be unfeasible in clinical application. The activity of the polygodyal-anethole compound was significantly better than polygodyal alone with high inoculum size and low pH. Moreover, it proved to exert a significantly faster biological activity against low inoculum. CONCLUSIONS: This study suggests that the mixture compound Kolorex has a very good profile of antifungal activity in terms of effectiveness and spectrum of action while being devoid of any significant toxicity. |
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Authors:
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Yussef Metugriachuk; Olivia Kuroi; Kanok Pavasuthipaisit; Junji Tsuchiya; Emilio Minelli; Ruichi Okura; Edoardo Fesce; F Marotta |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Chinese journal of digestive diseases Volume: 6 ISSN: 1443-9611 ISO Abbreviation: Chin J Dig Dis Publication Date: 2005 |
Date Detail:
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Created Date: 2005-05-20 Completed Date: 2005-10-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101088612 Medline TA: Chin J Dig Dis Country: Australia |
Other Details:
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Languages: eng Pagination: 98-103 Citation Subset: IM |
Affiliation:
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TMC Hospital, Shizuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anisoles Antifungal Agents / pharmacology*, toxicity Aspergillus flavus / drug effects Aspergillus fumigatus / drug effects Candida albicans / drug effects Candida tropicalis / drug effects Fungi / drug effects* Intestines / microbiology* Microbial Sensitivity Tests* Rats Sesquiterpenes / pharmacology*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Anisoles; 0/Antifungal Agents; 0/Sesquiterpenes; 104-46-1/anethole; 6754-20-7/polygodial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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