Document Detail

In the ventral tegmental area, G-proteins mediate progesterone's actions at dopamine type 1 receptors for lordosis of rats and hamsters.
MedLine Citation:
PMID:  16482481     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Previous reports indicate that the ventral tegmental area (VTA) and/or progesterone (P) can modulate the reinforcing effects of drugs of abuse, food, and sexual behavior. OBJECTIVES: We investigated if, in the VTA, P's membrane-mediated actions for lordosis involve dopamine type 1 receptors (D(1)). Also, whether P's actions at D(1) for lordosis are mediated by typical G-protein coupled mechanisms was examined. METHODS: In Exps 1 and 2, rats received estradiol (E(2) 10 microg) at h 0 and infusions of the D(1) antagonist SCH23390 (100 ng), the D(1) agonist SKF38393 (100 ng), or vehicle, to the VTA, at h 44. Thirty minutes later, rats received systemic P (0, 50, 100, or 200 microg). Subjects were tested for lordosis and motor behavior 2.5 h later. In Exps 3 and 4, E(2)+P (rats 0 or 100 microg; hamsters 200 microg)-primed animals were pretested for lordosis and motor behavior at h 47.5 and infused with SKF38393 (100 ng) or vehicle to the VTA. Thirty minutes later, subjects were retested and infused with the G-protein inhibitor guanosine 5'-O-(2-Thiodiphosphate) (GDP-beta-S; 50 microM) or vehicle. Post-testing occurred 30 min later. RESULTS: Pretreatment with SCH23390-reduced and SKF38393-enhanced P's actions, in the VTA, for lordosis of E(2)-primed rats and hamsters. As well, D(1)-mediated increases in P-facilitated lordosis of rats and hamsters were inhibited by GDP-beta-S. Changes in lordosis were independent of large alterations in motor behavior. CONCLUSIONS: In the VTA, P has actions for modulating reinforcing behaviors, such as lordosis, at D(1) that are G-protein-mediated.
Sandra M Petralia; Cheryl A Frye
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-02-16
Journal Detail:
Title:  Psychopharmacology     Volume:  186     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-16     Completed Date:  2006-10-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  133-42     Citation Subset:  IM    
Department of Psychology, The University at Albany, SUNY, Albany, NY, 12222, USA.
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MeSH Terms
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
Behavior, Animal / drug effects*,  physiology
Benzazepines / pharmacology
Dopamine Agonists / pharmacology
Dopamine Antagonists / pharmacology
GTP-Binding Proteins / metabolism*
Lordosis* / metabolism,  physiopathology
Motor Activity / drug effects,  physiology
Progesterone / pharmacology*
Rats, Long-Evans
Receptors, Dopamine D1 / agonists,  antagonists & inhibitors,  metabolism*
Ventral Tegmental Area / drug effects*,  metabolism
Grant Support
Reg. No./Substance:
0/Benzazepines; 0/Dopamine Agonists; 0/Dopamine Antagonists; 0/Receptors, Dopamine D1; 57-83-0/Progesterone; 67287-49-4/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; EC 3.6.1.-/GTP-Binding Proteins

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