Document Detail


In utero transplantation of haemopoietic stem cells.
MedLine Citation:
PMID:  11924915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In utero haematopoietic stem cell transplantation is a potentially valuable therapeutic approach that strives to take advantage of biological opportunities for cellular transplantation that exist in the early gestational fetus. However, with the exception of severe combined immunodeficiency, clinical application has been limited by minimal or no engraftment, suggesting the presence of significant barriers to engraftment within the fetal environnment. Research directed toward elucidating these barriers is progressing, and there is hope that the barriers to engraftment can be overcome in the near future. In the meantime, there are a limited number of specific disorders that are biologically favourable and may be amenable to treatment by this approach using conventional techniques. In the future, strategies that improve the competitive capacity of donor cells or the use of pre-natal transplantation to induce donor-specific tolerance followed by post-natal non-myeloablative enhancement of donor chimerism may allow broad clinical application of this approach.
Authors:
A W Flake
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical haematology     Volume:  14     ISSN:  1521-6926     ISO Abbreviation:  Best Pract Res Clin Haematol     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-04-01     Completed Date:  2003-04-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101120659     Medline TA:  Best Pract Res Clin Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  671-83     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Pennsylvania and Children's Hospital of Philadelphia, 19104-4933, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetal Diseases* / therapy*
Graft Survival
Humans
Pregnancy
Stem Cell Transplantation / methods*
Transplantation Chimera

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