Document Detail

In utero surgery for hydrocephalus.
MedLine Citation:
PMID:  12955423     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Neonatal hydrocephalus is one of the most common congenital anomalies affecting the nervous system.
DISCUSSION: Currently, ultrasonography allows for early detection of fetal ventriculomegaly and presents the family with several treatment options: termination of pregnancy, early delivery and neonatal shunting, and delivery at term followed by shunting. Despite ventricular decompression after birth, the cognitive outcome is variable as prolonged in utero hydrocephalus has a detrimental effect. In the early 1980s, fetal intervention was explored with the intention of improving outcome. However, patient selection was poor. Fetal ventriculomegaly from other conditions was not adequately distinguished from fetal hydrocephalus. In addition, fetal surgical techniques were not advanced. Consequently, the results were poor and a de facto moratorium on fetal shunting was imposed. However, recent improvements in fetal imaging, such as magnetic resonance imaging, and advances in fetal surgical techniques offer the possibility that properly selected fetuses with hydrocephalus can benefit from an in utero intervention.
Cornelia S von Koch; Nalin Gupta; Leslie N Sutton; Peter P Sun
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Publication Detail:
Type:  Historical Article; Journal Article; Review     Date:  2003-07-25
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  19     ISSN:  0256-7040     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-04     Completed Date:  2003-12-04     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  574-86     Citation Subset:  IM    
Department of Neurological Surgery, University of California San Francisco, Room M-779, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143-0112, USA.
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MeSH Terms
Cerebrospinal Fluid Shunts / methods*
Disease Models, Animal
Embryonic and Fetal Development
Fetal Diseases / pathology,  surgery*
History, 20th Century
History, 21st Century
Hydrocephalus / classification,  diagnosis,  history,  surgery*
Intracranial Pressure
Prenatal Diagnosis / methods

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