Document Detail


In-utero sensitization modulates IgG isotype, IFN-γ and IL-10 responses of neonates in bancroftian filariasis.
MedLine Citation:
PMID:  24902619     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In-utero exposure has been considered as a risk factor for filarial infection. To evaluate the influence of maternal infection on filarial specific IgG subclass response in neonates and their correlation with plasma levels IL-10 and Interferon-γ, 145 pairs of mothers and their respective cord bloods were examined. Transpalcental transfer of circulating filarial antigen (CFA) was observed in 34.8% cord bloods from CFA positive mothers. Filarial specific IgG1, IgG2 and IgG4 responses of cord bloods were found to be positively correlated with CFA of mothers. In contrast IgG3 responses negatively correlated with CFA of mothers. The% of similarity of recognition pattern in the cord blood with maternal blood was high for IgG3 response than IgG4 in all three groups. An increased levels of IL-10 and decreased levels of IFN- γ were observed in cord blood of infected mothers. IFN-γ was positively correlated with IgG3 and negatively correlated with IgG4 level. On the other hand IL-10 was positively correlated with IgG4 and CFA indicating that cytokines may play a role in modulating the immune responses in cord bloods of sensitized foetus. The findings of the study reveal that in-utero tolerance or sensitization may influence the filarial-specific immunity to infection in neonates. This article is protected by copyright. All rights reserved.
Authors:
K G Achary; N N Mandal; S Mishra; R Mishra; S S Sarangi; A K Satapathy; S K Kar; M S Bal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-5
Journal Detail:
Title:  Parasite immunology     Volume:  -     ISSN:  1365-3024     ISO Abbreviation:  Parasite Immunol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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