Document Detail

In utero rearrangements in the trithorax-related oncogene in infant leukaemias.
MedLine Citation:
PMID:  8497319     Owner:  NLM     Status:  MEDLINE    
The majority (approximately 75%) of infant acute leukaemias have a reciprocal translocation between chromosome 11q23 and one of several partner chromosomes. The gene at 11q23 (named MLL, ALL-1, HRX or HTRX-1; refs 2-6) has been cloned and shares homology with the Drosophila developmental gene trithorax. Rearrangements of this gene (called HRX here) occur in introns and cluster in a region of approximately 10 kb; individual patients have different breakpoints. Here we describe three pairs of infant twins with concordant leukaemia who each share unique (clonal) but non-constitutive HRX rearrangements in their leukaemic cells, providing evidence that the leukaemogenic event originates in utero and unequivocal support for the intra-placental 'metastasis' hypothesis for leukaemia concordance in twins.
A M Ford; S A Ridge; M E Cabrera; H Mahmoud; C M Steel; L C Chan; M Greaves
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  363     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-24     Completed Date:  1993-06-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  358-60     Citation Subset:  IM    
Leukaemia Research Fund Centre, Chester Beatty Laboratories, London, UK.
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MeSH Terms
Chromosomes, Human, Pair 11
Clone Cells
DNA-Binding Proteins / genetics*
Diseases in Twins / genetics*
Dosage Compensation, Genetic
Gene Rearrangement*
Gene Rearrangement, B-Lymphocyte
Gene Rearrangement, T-Lymphocyte
Myeloid-Lymphoid Leukemia Protein
Neoplasm Metastasis
Precursor Cell Lymphoblastic Leukemia-Lymphoma / embryology*,  genetics*
Transcription Factors*
Twins, Monozygotic
Reg. No./Substance:
0/DNA-Binding Proteins; 0/MLL protein, human; 0/Transcription Factors; 149025-06-9/Myeloid-Lymphoid Leukemia Protein

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