Document Detail


In utero rearrangements in the trithorax-related oncogene in infant leukaemias.
MedLine Citation:
PMID:  8497319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The majority (approximately 75%) of infant acute leukaemias have a reciprocal translocation between chromosome 11q23 and one of several partner chromosomes. The gene at 11q23 (named MLL, ALL-1, HRX or HTRX-1; refs 2-6) has been cloned and shares homology with the Drosophila developmental gene trithorax. Rearrangements of this gene (called HRX here) occur in introns and cluster in a region of approximately 10 kb; individual patients have different breakpoints. Here we describe three pairs of infant twins with concordant leukaemia who each share unique (clonal) but non-constitutive HRX rearrangements in their leukaemic cells, providing evidence that the leukaemogenic event originates in utero and unequivocal support for the intra-placental 'metastasis' hypothesis for leukaemia concordance in twins.
Authors:
A M Ford; S A Ridge; M E Cabrera; H Mahmoud; C M Steel; L C Chan; M Greaves
Related Documents :
395589 - Chromosome changes and benzene exposure. a review.
12691999 - Recsim and indstats: probabilities of identity in general genealogies.
806509 - The somatic chromosome complement and the idiogram of pithecia pithecia pithecia (linna...
6967249 - Clinical and experimental studies on the incorporation of materials applied as covering...
269009 - Quantification by dna-based cytophotometry of the 9q+/22q-chromosomal translocation ass...
3422539 - Clinical presentation and natural history of patients with essential thrombocythemia an...
25296379 - Alternative meiotic chromatid segregation in the holocentric plant luzula elegans.
6202819 - Chromosomal translocations activating myc sequences and transduction of v-abl are criti...
24258349 - The effect of minimal concentration of ethylene glycol (eg) combined with polyvinylpyrr...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  363     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-24     Completed Date:  1993-06-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  358-60     Citation Subset:  IM    
Affiliation:
Leukaemia Research Fund Centre, Chester Beatty Laboratories, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Pair 11
Clone Cells
DNA-Binding Proteins / genetics*
Diseases in Twins / genetics*
Dosage Compensation, Genetic
Female
Gene Rearrangement*
Gene Rearrangement, B-Lymphocyte
Gene Rearrangement, T-Lymphocyte
Humans
Infant
Male
Myeloid-Lymphoid Leukemia Protein
Neoplasm Metastasis
Oncogenes*
Placenta
Precursor Cell Lymphoblastic Leukemia-Lymphoma / embryology*,  genetics*
Pregnancy
Proto-Oncogenes*
Transcription Factors*
Twins, Monozygotic
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/MLL protein, human; 0/Transcription Factors; 149025-06-9/Myeloid-Lymphoid Leukemia Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF.
Next Document:  Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte ...