| In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice. | |
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MedLine Citation:
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PMID: 20398696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Environmental-level in utero and lactational exposures to dioxins have been considered to affect brain functions of offspring. Here, we determined whether in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD), at the dose that does not harm the dams, affects the acquisition and retention of fear memory in mouse offspring. Pregnant C57BL/6J mice were administered by gavages TCDD or TBDD at a dose of 0 or 3.0 microg/kg body weight on gestation day 12.5, and their male offspring were examined for their behavior in adulthood. In the fear conditioning, a paired presentation of tone and foot shock was repeated three times, and retention tests for contextual and auditory fear memory were carried out 1 and 24h after the fear conditioning. Groups of mice that were exposed to TCDD and TBDD in utero and via lactation showed deficits in the contextual and auditory retention tests at 1 and 24h retention intervals. The present results suggest that maternal exposure to a low dose of TCDD or TBDD disrupts the functions of memory and emotion in male mouse offspring, and that the developmental toxicities of these chemicals are similar to each other. |
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Authors:
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Asahi Haijima; Toshihiro Endo; Yan Zhang; Wataru Miyazaki; Masaki Kakeyama; Chiharu Tohyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-14 |
Journal Detail:
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Title: Neurotoxicology Volume: 31 ISSN: 1872-9711 ISO Abbreviation: Neurotoxicology Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-06-07 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 385-90 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breast Feeding / adverse effects* Conditioning, Classical / drug effects Dioxins / administration & dosage, toxicity* Environmental Pollutants / administration & dosage, toxicity* Fear / psychology* Female Lactation Male Memory / drug effects* Mice Mice, Inbred C57BL Pregnancy Prenatal Exposure Delayed Effects / psychology* Tetrachlorodibenzodioxin / administration & dosage, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Dioxins; 0/Environmental Pollutants; 1746-01-6/Tetrachlorodibenzodioxin; 50585-41-6/2,3,7,8-tetrabromodibenzo-4-dioxin |
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