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In utero hematopoietic cell transplantation for the treatment of congenital anomalies.
MedLine Citation:
PMID:  22682381     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In utero hematopoietic cell transplantation (IUHCTx) is a promising strategy for the treatment of common hematopoietic disorders and for inducing immune tolerance in the fetus. Although the efficacy of IUHCTx has been demonstrated in multiple small and large animal models, the clinical application of this technique in humans has had limited success. Recent studies in mice have demonstrated that the maternal immune system plays a critical role in limiting engraftment in the fetus. This article reviews the therapeutic rationale of IUHCTx, potential barriers to its applications, and recent experimental strategies to improve its clinical success.
Authors:
Amar Nijagal; Alan W Flake; Tippi C Mackenzie
Publication Detail:
Type:  Journal Article     Date:  2012-05-08
Journal Detail:
Title:  Clinics in perinatology     Volume:  39     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Surgery, 513 Parnassus Avenue, San Francisco, CA 94143-0570, USA.
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