Document Detail

In utero exposure to tobacco smoke and subsequent reduced fertility in females.
MedLine Citation:
PMID:  20817739     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Animal studies have shown that in utero exposure to chemicals in tobacco smoke reduces female fertility, but epidemiological findings have been inconsistent.
METHODS: We examined the association between in utero exposure to tobacco smoke and female fertility among women in the Norwegian Mother and Child Cohort Study, enrolled from 1999 to 2007. Around the 17th week of pregnancy, participants reported how long they took to conceive (time to pregnancy), and whether their mother smoked while pregnant with the participant. This analysis included 48 319 planned pregnancies among women aged 15-44 years. We estimated fecundability odds ratios (FORs) using a discrete-time survival analysis, adjusting for age, education and adult tobacco smoking.
RESULTS: The adjusted FOR for in utero exposure to tobacco smoke among all subjects was 0.96 [95% confidence interval (CI): 0.93, 0.98], among subjects reporting no adult tobacco smoking or passive exposure it was 0.96 (95% CI: 0.93, 0.99) and among subjects reporting adult tobacco smoking or passive exposure it was 0.95 (95% CI: 0.91, 0.99). We performed a probabilistic sensitivity analysis to estimate the effect of exposure and outcome misclassification on the results, and, as expected, the association became more pronounced after taking misclassification into account.
CONCLUSIONS: This large cohort study supports a small-to-modest association between in utero exposure to tobacco smoke and reduced fertility.
Xibiao Ye; Rolv Skjaerven; Olga Basso; Donna D Baird; Merete Eggesbo; Lea Aurora Cupul Uicab; Kjell Haug; Matthew P Longnecker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2010-09-03
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  25     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-02-03     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2901-6     Citation Subset:  IM    
Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Human and Health Services, Research Triangle Park, NC 27709, USA.
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MeSH Terms
Fertility / drug effects*
Infertility, Female / etiology
Prenatal Exposure Delayed Effects
Smoking / adverse effects*
Tobacco Smoke Pollution / adverse effects*
Grant Support
1 U01 NS 047537-01/NS/NINDS NIH HHS; N01-ES-85433/ES/NIEHS NIH HHS
Reg. No./Substance:
0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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