Document Detail


In-utero exposure to maternal smoking is not linked to tobacco use in adulthood after controlling for genetic and family influences: a Swedish sibling study.
MedLine Citation:
PMID:  24840229     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Previous studies have linked maternal smoking during pregnancy with regular tobacco use in offspring, but findings are not consistent and confounding from genetic and environmental factors have not fully been taken into account. A comparison between siblings discordant for prenatal smoking exposure adjusts for confounding by shared familial (i.e., genetic and environmental) factors. We investigated the association between prenatal exposure to maternal smoking during pregnancy and the risk of regular smoking or snus (Swedish moist smokeless tobacco) use in young adult offspring, using a population based matched cohort study. The cohort consisted of 1,538 randomly sampled same-sex sibling pairs, discordant for maternal smoking during pregnancy, 19-27 years old, participating in a survey conducted in Sweden 2010-2011. Lifetime and current history of tobacco use was self-reported in the survey, and information about maternal smoking during pregnancy was retrieved from the Medical Birth Register. Conditional logistic regression and stratified Cox proportional hazards regression were used to calculate odds ratios, hazard ratios, and corresponding 95 % confidence intervals. Analyses of exposure-discordant siblings did not reveal significant associations between prenatal exposure to maternal smoking and lifetime or current daily tobacco use, intensity of use, or time to onset of daily tobacco use. These findings suggest that the previously reported higher risks of tobacco use in offspring of mothers who smoked during pregnancy, compared with offspring of non-smoking mothers, were likely due to confounding from genetic or environmental factors.
Authors:
Mina Rydell; Fredrik Granath; Sven Cnattingius; Cecilia Magnusson; Maria Rosaria Galanti
Related Documents :
24607049 - Maternal second-hand smoke exposure in pregnancy is associated with childhood asthma de...
23062369 - Focused-ultrasound termination of an early pregnancy in rhesus macaques (macaca mulatta...
25150119 - Iron deficiency without anemia causes maternal hypothyroxinemia in pregnant rats.
6835609 - Pathologic fetal heart rate associated with poor metabolic control in diabetic pregnanc...
23892639 - Organophosphate urinary metabolite levels during pregnancy, delivery and postpartum in ...
22985739 - Environmental exposure to arsenic and cadmium during pregnancy and fetal size: a longit...
16867159 - Placental expression of glycophosphatidylinositol (gpi)-anchored proteins in paroxysmal...
9469279 - Three-dimensional ultrasonographic assessments of fetal development.
19864339 - Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic precond...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-20
Journal Detail:
Title:  European journal of epidemiology     Volume:  -     ISSN:  1573-7284     ISO Abbreviation:  Eur. J. Epidemiol.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508062     Medline TA:  Eur J Epidemiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The German National Cohort: aims, study design and organization.
Next Document:  Physical activity and survival of postmenopausal, hormone receptor-positive breast cancer patients: ...