Document Detail

In utero development of symmetric thalamic and brainstem necrosis in a preterm hydropic stillborn.
MedLine Citation:
PMID:  21073840     Owner:  NLM     Status:  MEDLINE    
Focal and symmetric necrotic lesions of the brainstem are thought to result from fetal hypotension or cardiac arrest in the perinatal period and thus occur in the course of postnatal intensive care rather than in utero. Here, we report for the first time on brainstem necrosis in a preterm stillborn demonstrating that brainstem necrosis occurs already in utero. The preterm stillborn of 28 weeks gestation of a mother that suffered from HELLP-syndrome was severely affected by a fetal hydrops with bilateral pleural effusions and lung hypoplasia. Bilateral tegmental brainstem necrosis and thalamic lesions were detected.
D P Szekessy; C Bamberg; C Blechschmidt; A M Kaindl; G Stoltenburg-Didinger
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neuropathology     Volume:  29     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  365-71     Citation Subset:  IM    
Department of Neonatology, Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.
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MeSH Terms
Brain Stem / pathology*
HELLP Syndrome / diagnosis
Hydrops Fetalis / pathology*
Infant, Newborn
Necrosis / diagnosis,  pathology
Premature Birth*
Thalamus / pathology*

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