Document Detail

In utero development of hypertensive necrotizing pulmonary arterial lesions: report of a case associated with premature closure of the ductus arteriosus and pulmonary hypoplasia.
MedLine Citation:
PMID:  10739906     Owner:  NLM     Status:  MEDLINE    
Premature closure of the ductus arteriosus (PCDA) is an uncommon defect in which pulmonary hypertension (PH) has been documented by echocardiography in patients and by direct measurement after experimental PCDA in animals. The pulmonary vascular histology in human cases has received little attention but in the few recorded observations the vessels were either normal or showed increased muscularity. We report the case of a 31 week hydropic female stillborn monozygotic twin in whom postmortem examination disclosed PCDA and hypoplasia of the lungs. Atypical plexiform lesions with necrotizing pulmonary arteritis were present. These lesions represent vascular consequences of severe pulmonary hypertension produced by greatly enhanced blood flow through a restricted vascular bed resulting from the combined effects of these two abnormalities. The findings in this case of PCDA with presumed severe PH indicate that severe pulmonary vascular changes can develop in utero and that the interval of time needed for development of such chances in secondary PH is relatively short.
C E Oyer; L R Feit; B B Rogers; C Kuhn
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  9     ISSN:  1054-8807     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2000 Jan-Feb
Date Detail:
Created Date:  2000-05-16     Completed Date:  2000-05-16     Revised Date:  2006-11-03    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-47     Citation Subset:  IM    
Department of Pathology, Women and Infants' Hospital and Brown University School of Medicine, Providence, Rhode Island 02906, USA.
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MeSH Terms
Arteritis / congenital*,  pathology
Diseases in Twins*
Ductus Arteriosus / abnormalities*
Fetal Death
Heart Defects, Congenital / complications*,  pathology
Hydrops Fetalis / etiology,  pathology
Hypertension, Pulmonary / etiology*,  pathology
Lung / abnormalities*,  blood supply
Pulmonary Artery / pathology*
Twins, Monozygotic

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