| In utero central nervous system damage in pyruvate dehydrogenase deficiency. | |
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MedLine Citation:
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PMID: 3137916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pyruvate dehydrogenase deficiency is among the most common causes of congenital lactic acidosis. We describe siblings with congenital lactic acidosis due to a deficiency of pyruvate dehydrogenase complex. The findings of computed tomography and pathologic studies suggest that central nervous system damage had occurred in utero. These observations have implications for treatment and outcome in patients with enzymatic defects causing congenital lactic acidosis. |
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Authors:
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K A Aleck; A M Kaplan; W G Sherwood; B H Robinson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of neurology Volume: 45 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-09-29 Completed Date: 1988-09-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 987-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Phoenix Children's Hospital, AZ 85006. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain
/
embryology,
pathology*,
radiography Female Fetal Diseases / genetics, pathology*, radiography Fetus / anatomy & histology Humans Infant, Newborn Ketoglutarate Dehydrogenase Complex / metabolism Male Pregnancy Pyruvate Dehydrogenase Complex / metabolism Pyruvate Dehydrogenase Complex Deficiency Disease* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Pyruvate Dehydrogenase Complex; EC 1.2.4.2/Ketoglutarate Dehydrogenase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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