Document Detail


In utero anaphylaxis.
MedLine Citation:
PMID:  20850225     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Late fetal demise and hypoxic-ischemic neurologic injury after previously normal in utero development remain devastating outcomes of pregnancy, for which no cause is identified in many cases. Based on a case encountered, I propose that some of these incidents may be due to in utero anaphylaxis to food antigens that cross the placenta. Potential allergens to which pregnant women are exposed can be transported across the placenta, and the fetus is capable of producing IgE, the antibody responsible for anaphylaxis in humans. Whether this IgE is antigen specific is controversial with some studies indicating the ability to generate IgE to food antigens prenatally. Indirect evidence for in utero production of specific IgE is the high percentage of food reactions that occur on the first postnatal exposure to the food. I propose that some cases of stillbirth and prenatal hypoxic-ischemic injury may be due to in utero anaphylaxis.
Authors:
Andrew MacGinnitie
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Publication Detail:
Type:  Journal Article     Date:  2010-09-17
Journal Detail:
Title:  Medical hypotheses     Volume:  76     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-2     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of UPMC, Department of Pediatrics, University of Pittsburgh School of Medicine, 4401 Penn Ave., Pittsburgh, PA 15224, USA. macginnitieaj@upmc.edu
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