| In utero aminoglycosides-induced nephrotoxicity in rat neonates. | |
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MedLine Citation:
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PMID: 3352159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnant Wistar females were treated with gentamicin (G), netilmicin (N) or amikacin (A) during two periods of pregnancy covering organogenesis and the beginning of nephrogenesis. Deliveries occurred normally. We studied functional effects--influence of sex, litter size, diuresis, creatinine clearance, G-kidney concentration, and kidney morphological alterations--in rat neonates on day 1 of life. After G and N, the creatinine clearance of the neonates was decreased according to the dosage given to the mother. Whatever the aminoglycoside, kidneys presented proximal tubular alterations (close to those observed in adults) at protonic microscopy and, with electron microscopy, some modifications of distal tubules and of mature and immature glomeruli. It is concluded that the developing kidney can be altered after treating pregnant mothers with aminoglycosides. This model of in utero-induced nephrotoxicity is dose-dependent. Mature and/or immature structures could be affected. The toxicity of the investigated antibiotics could be asserted as G greater than or equal to N greater than A. |
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Authors:
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J P Mallié; G Coulon; C Billerey; A Faucourt; J P Morin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Kidney international Volume: 33 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-05-10 Completed Date: 1988-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 36-44 Citation Subset: IM |
Affiliation:
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Laboratoire de Néphrologie, Université de Nancy I, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amikacin
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toxicity Animals Animals, Newborn Anti-Bacterial Agents / toxicity* Creatinine / pharmacokinetics Female Gentamicins / toxicity Kidney / drug effects*, pathology, physiopathology Maternal-Fetal Exchange Microscopy, Electron Netilmicin / toxicity Pregnancy Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Gentamicins; 37517-28-5/Amikacin; 56391-56-1/Netilmicin; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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