| In utero alcohol exposure and prediction of alcohol disorders in early adulthood: a birth cohort study. | |
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MedLine Citation:
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PMID: 16953003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Little is known about the contribution of fetal alcohol exposure to the development of alcohol disorders in early adulthood. OBJECTIVE: To examine the independent effect of maternal alcohol use during early vs late periods in pregnancy on the time of onset of alcohol disorders in offspring. DESIGN: Follow-up study of the Mater-University of Queensland Study of Pregnancy and Its Outcomes (MUSP), a population-based birth cohort study commenced in Brisbane, Australia, in 1981 and designed to examine the association of maternal alcohol exposure with the onset of alcohol disorders. Mothers and children were followed up at birth, 6 months, and 5, 14, and 21 years after the initial interview. Maternal alcohol use was assessed before pregnancy, in early and late pregnancy, and at the 5- and 14-year follow-up visits. Alcohol disorders in early adulthood were assessed at age 21 years using the lifetime version of the Composite International Diagnostic Interview-computerized version. SETTING: Population-based birth cohort study. PARTICIPANTS: A subsample of 2138 participants for whom complete data were available at the 21-year follow-up. MAIN OUTCOME MEASURE: Onset of alcohol disorder from adolescence to 21 years of age. RESULTS: In utero alcohol exposure of 3 or more glasses was associated with alcohol disorders. The fully adjusted odds ratios (95% confidence intervals) of developing early-onset alcohol disorders at age 21 years were 2.95 (1.62-5.36) for those exposed to maternal drinking in early pregnancy and 1.35 (0.69-2.63) for those exposed in late pregnancy. There was also a strong association between alcohol exposure in early pregnancy and late-onset alcohol disorders (odds ratio, 3.29 [95% confidence interval, 1.74-6.24]). CONCLUSIONS: Our results provide support for a biological origin of adult alcohol disorders and suggest that the association is not explained solely by maternal drinking or smoking during childhood and adolescence or other intervening factors. Further research is needed to understand the mechanisms underlying the association. |
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Authors:
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Rosa Alati; Abdullah Al Mamun; Gail M Williams; Michael O'Callaghan; Jake Moses Najman; William Bor |
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16257353 - Alcohol consumption and serum hormone levels during pregnancy. 7195993 - Neoplasia and the fetal alcohol and hydantoin syndromes. 15774513 - Periconceptional nutrition and the relationship between maternal body weight changes in... |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of general psychiatry Volume: 63 ISSN: 0003-990X ISO Abbreviation: Arch. Gen. Psychiatry Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-05 Completed Date: 2006-09-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372435 Medline TA: Arch Gen Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 1009-16 Citation Subset: AIM; IM |
Affiliation:
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School of Population Health, The University of Queensland, Medical School, Public Health Building, Herston, Queensland 4006, Australia. r.alati@aph.uq.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Alcohol Drinking / adverse effects* Alcohol-Related Disorders / diagnosis, epidemiology* Alcoholism / diagnosis, epidemiology Australia / epidemiology Child, Preschool Cohort Studies Ethanol / adverse effects Female Follow-Up Studies Humans Infant Infant, Newborn Longitudinal Studies Male Maternal Exposure* Multivariate Analysis Pregnancy Prenatal Exposure Delayed Effects* Prospective Studies Psychiatric Status Rating Scales |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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