Document Detail


In utero and lactation exposure of mice to pan masala: effect on dams and pregnancy outcome.
MedLine Citation:
PMID:  21609317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pan masala, a chewing mixture, is a popular alternate of areca nut/tobacco/betal quid in various parts of the world. In view of embryotoxic effects of areca nut and tobacco, it is hypothesized that in utero and lactational exposure to pan masala plain (PMP, containing areca nut as major ingredient), and pan masala with tobacco (PMT) can also have similar effects. To investigate this, pregnant female Swiss albino mice were treated with 3 and 6% of PMP and PMT from gestation day (GD) 0, 6, and 14 until lactation. They were weighed during pregnancy and lactation. At parturition, pups were counted, weighed, and measured. At weaning, dams were sacrificed for implantation count. Three percent and 6% PMT considerably reduced female fertility. Gestation length was lower in all the pan masala–treated mice, which was significant at 3 and 6% PMT treatment from GD 0. Pups born to pan masala–treated dams had significantly low birth weight at 3 and 6% PMT in GD 0 and GD 6, and 6% PMT in the GD 14 group. Sex ratio declined in the GD 0 pan masala–treated group. Neonatal death was observed in all the pan masala–treated groups from GD 0 and 6% of both PMP- and PMT-treated groups from GD 14 with respect to control. Weaning index was considerably altered in GD 0 and 14 pan masala–treated groups. Postimplantation loss was considerably high in all the pan masala–treated groups. The data points toward the in utero and lactational fetotoxic effects of pan masala treatment, mainly PMT.
Authors:
K Archana; A K Gautam; B C Lakkad; Sunil Kumar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer     Volume:  30     ISSN:  2162-6537     ISO Abbreviation:  J. Environ. Pathol. Toxicol. Oncol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-25     Completed Date:  2011-07-26     Revised Date:  2011-12-29    
Medline Journal Info:
Nlm Unique ID:  8501420     Medline TA:  J Environ Pathol Toxicol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-81     Citation Subset:  IM    
Affiliation:
Division of Reproductive and Cytotoxicology, National Institute of Occupational Health, Ahmedabad, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Areca / adverse effects*
Birth Weight
Female
Fertility
Fetal Weight
Fetus / drug effects*
Litter Size
Male
Mice
Pregnancy
Pregnancy Outcome
Tobacco, Smokeless / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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