| In utero HIV infection is associated with an increased risk of nevirapine resistance in ugandan infants who were exposed to perinatal single dose nevirapine. | |
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MedLine Citation:
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PMID: 19552593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Use of single dose nevirapine (sdNVP) to prevent HIV mother-to-child transmission is associated with the emergence of NVP resistance in many infants who are HIV infected despite prophylaxis. We combined results from four clinical trials to analyze predictors of NVP resistance in sdNVP-exposed Ugandan infants. Samples were tested with the ViroSeq HIV Genotyping System and a sensitive point mutation assay (LigAmp, for detection of K103N, Y181C, and G190A). NVP resistance was detected at 6-8 weeks in 36 (45.0%) of 80 infants using ViroSeq and 33 (45.8%) of 72 infants using LigAmp. NVP resistance was more frequent among infants who were infected in utero than among infants who were diagnosed with HIV infection after birth by 6-8 weeks of age. Detection of NVP resistance at 6-8 weeks was not associated with HIV subtype (A vs. D), pre-NVP maternal viral load or CD4 cell count, infant viral load at 6-8 weeks, or infant sex. NVP resistance was still detected in some infants 6-12 months after sdNVP exposure. In this study, in utero HIV infection was the only factor associated with detection of NVP resistance in infants 6-8 weeks after sdNVP exposure. |
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Authors:
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Jessica D Church; Anthony Mwatha; Danstan Bagenda; Saad B Omer; Deborah Donnell; Philippa Musoke; Clemensia Nakabiito; Chineta Eure; Paul Bakaki; Flavia Matovu; Michael C Thigpen; Laura A Guay; Michelle McConnell; Mary Glenn Fowler; J Brooks Jackson; Susan H Eshleman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 25 ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-22 Completed Date: 2009-09-22 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: United States |
Other Details:
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Languages: eng Pagination: 673-7 Citation Subset: IM; X |
Affiliation:
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Johns Hopkins University School of Medicine , Baltimore, Maryland 21205, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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administration & dosage* CD4 Lymphocyte Count Clinical Trials as Topic Drug Administration Schedule Drug Resistance, Viral* Female HIV / drug effects*, genetics HIV Infections / drug therapy*, immunology, transmission Humans Infant Infectious Disease Transmission, Vertical Nevirapine / administration & dosage* Pregnancy Pregnancy Complications, Infectious / drug therapy*, virology RNA, Viral / analysis, drug effects, genetics Uganda Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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AI-045200/AI/NIAID NIH HHS; N01 AI035173/AI/NIAID NIH HHS; N01 AI045200/AI/NIAID NIH HHS; N01-AI-035173/AI/NIAID NIH HHS; N01-AI-035173-417/AI/NIAID NIH HHS; R01 AI034235-06S1/AI/NIAID NIH HHS; R01-AI-034235-04/AI/NIAID NIH HHS; U01 AI038576-07S3/AI/NIAID NIH HHS; U01 AI046745-01/AI/NIAID NIH HHS; U01 AI048054-01/AI/NIAID NIH HHS; U01 AI068613-04/AI/NIAID NIH HHS; U01 AI068632-02/AI/NIAID NIH HHS; U01 AI068632-03/AI/NIAID NIH HHS; U01-AI-038576-07/AI/NIAID NIH HHS; U01-AI-046745/AI/NIAID NIH HHS; U01-AI-048054/AI/NIAID NIH HHS; U01-AI-068613/AI/NIAID NIH HHS; U01-AI-068632/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/RNA, Viral; 129618-40-2/Nevirapine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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