| In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to <5 copies per milliliter, with a half-life of 6 months. | |
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MedLine Citation:
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PMID: 12525664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three of five virally suppressed human immunodeficiency virus type I (HIV-1)-infected patients treated with highly active antiretroviral therapy and followed intensively with a supersensitive reverse transcriptase PCR assay with a lower limit of quantitation of 5 copies/ml showed statistically significant viral load decays below 50 copies/ml, with half-lives of 5 to 8 months and a mean of 6 months. This range of half-lives is consistent with the estimated half-life of the latent HIV-1 reservoir in the peripheral blood. Those patients without decay of viral load in plasma may have significant cryptic HIV-1 residual replication. |
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Authors:
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Michele Di Mascio; Geethanjali Dornadula; Hui Zhang; Julie Sullivan; Yan Xu; Joseph Kulkosky; Roger J Pomerantz; Alan S Perelson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of virology Volume: 77 ISSN: 0022-538X ISO Abbreviation: J. Virol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-14 Completed Date: 2003-02-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 2271-5 Citation Subset: IM |
Affiliation:
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Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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drug therapy*,
virology Antiretroviral Therapy, Highly Active* CD4-Positive T-Lymphocytes / virology HIV-1 / drug effects* Half-Life Humans RNA, Viral / blood* Regression Analysis Reverse Transcriptase Polymerase Chain Reaction Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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AI28433/AI/NIAID NIH HHS; AI46289/AI/NIAID NIH HHS; RR06555/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Viral |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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