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In situ remineralisation of eroded enamel lesions by NaF rinses.
MedLine Citation:
PMID:  22041022     Owner:  NLM     Status:  Publisher    
OBJECTIVE: The purpose of this pilot study was to evaluate the remineralisation of eroded enamel by NaF rinses in an intra-oral model. METHODS: Serving as their own control, subjects (N=80) participated in a randomised, four-leg (20 subjects/leg), 28-day, parallel design study. In each leg, each participant wore a customised orthodontic bracket attached to a mandibular molar that contained one tooth block having an initial erosive lesion (0.3% citric acid, pH 3.75, 2h). Within the 28-day period, participants engaged in twice-daily brushing for 1min with a fluoride-free dentifrice followed by 1-min rinsing with one of the following aqueous rinses: fluoride-free (0ppm F), 225ppm F, 225ppm F plus functionalised β-tricalcium phosphate (fTCP), and 450ppm F. Following intra-oral exposure, appliances were removed and specimens were analysed using surface microhardness (SMH) and transverse microradiography (TMR). RESULTS: Statistically significant (p<0.05) remineralisation, as determined by SMH and TMR, of the eroded enamel relative to baseline occurred for each fluoride system. No significant differences in SMH were observed amongst the fluoride groups (p>0.05), however, 225ppm plus fTCP produced 27% and 7% SMH indent length reduction relative to 225ppm F and 450ppm F, respectively. No significant differences in TMR were observed amongst the fluoride groups (p>0.05), however, 225ppm F plus fTCP and 450ppm F produced significant (p<0.05) mineral gains relative to the fluoride-free control, whilst 225ppm F did not (p>0.05). Relative to the 225ppm F group, the 450ppm F and 225ppm F plus fTCP groups produced 65% and 61% greater mineral change, respectively. CONCLUSIONS: These pilot results demonstrate this model is sensitive to fluoride and that addition of fTCP to an aqueous rinse containing 225ppm F may provide significant remineralisation benefits. Therefore, the combination of relatively low levels of fluoride and fTCP might be an effective alternative to a high fluoride treatment for anti-erosion benefits.
Mary S Mathews; Bennett T Amaechi; Karthikeyan Ramalingam; Renzo A Ccahuana-Vasquez; Irene P Chedjieu; Allen C Mackey; Robert L Karlinsey
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-29
Journal Detail:
Title:  Archives of oral biology     Volume:  -     ISSN:  1879-1506     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
University of Texas Health Science Center at San Antonio, Department of Comprehensive Dentistry, MC 7914, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
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