Document Detail

In situ intestinal absorption of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid in guinea pigs.
MedLine Citation:
PMID:  7562119     Owner:  NLM     Status:  MEDLINE    
The intestinal absorption efficacy of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), which has been recently synthesized and characterized as a stable ascorbate (AsA), was determined in guinea pigs by the perfusion technique. Perfusion of AA-2G in isotonic phosphate buffer to the small intestine resulted in a decrease of AA-2G accompanied by an increase of AsA in the perfusate. The results showed that intact AA-2G was not detected in the plasma of the portal vein of guinea pigs at 2 h after perfusion. The disappearance of AA-2G from perfusate was completely inhibited by the addition of castanospermine, a specific alpha-glucosidase inhibitor, or by carbohydrates such as maltose. These results indicate that ascorbic acid released from AA-2G by alpha-glucosidase on the brush border membrane is effectively taken up across the intestinal ascorbate transport channels, into a serosal site, whereas AA-2G permeation was poor via the passive transport system.
H Wakamiya; E Suzuki; I Yamamoto; M Akiba; N Arakawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  41     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-11-02     Completed Date:  1995-11-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  265-72     Citation Subset:  IM    
Division of Human Science and Technology, Ochanomizu University, Tokyo, Japan.
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MeSH Terms
Ascorbic Acid / analogs & derivatives*,  blood,  metabolism,  pharmacokinetics
Carbohydrates / pharmacology
Enzyme Inhibitors / pharmacology
Guinea Pigs
Hydrolysis / drug effects
Indolizines / pharmacology
Intestinal Absorption / drug effects,  physiology*
Intestine, Small / drug effects,  metabolism,  physiology*
Maltose / pharmacology
alpha-Glucosidases / antagonists & inhibitors
Reg. No./Substance:
0/Carbohydrates; 0/Enzyme Inhibitors; 0/Indolizines; 129499-78-1/ascorbic acid 2-O-glucoside; 50-81-7/Ascorbic Acid; 69-79-4/Maltose; 79831-76-8/castanospermine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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