Document Detail


In situ hybridization of two markers closely flanking the spinal muscular atrophy gene to 5q12----q13.3.
MedLine Citation:
PMID:  1914518     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to refine the physical location of the p105-153Ra and M4 probes which closely flank the spinal muscular atrophy gene (SMA) on human chromosome 5q, in situ hybridization has been carried out on prometaphase chromosomes. Our results demonstrate that the disease gene is located between the 5q12----q13.1 and 5q13.3 bands. The present study will hopefully contribute to microdissection of the chromosomal region of the SMA gene.
Authors:
M G Mattei; J Melki; M F Bachelot; S Abdelhak; P Burlet; J Frézal; A Munnich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  57     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-05     Completed Date:  1991-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  112-3     Citation Subset:  IM    
Affiliation:
Unité de Recherches de Physiopathologie Chromosomique, INSERM U-242, Hôpital de La Timone, Marseille, France.
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MeSH Terms
Descriptor/Qualifier:
Child
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 12*
Humans
Karyotyping
Muscular Atrophy, Spinal / genetics*
Nucleic Acid Hybridization

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