Document Detail

In situ heparin-induced peroxisomal reticulum and biogenesis of peroxisomes in pulmonary intravascular macrophages (PIMs) of caprine lung: an ultrastructural and cytochemical study.
MedLine Citation:
PMID:  11748573     Owner:  NLM     Status:  MEDLINE    
Pulmonary intravascular macrophages (PIMs) contain a unique electron-dense globular surface-coat which is sensitive to heparin treatment, halothane anesthesia, and the digestive effect of lipolytic lipase (LPL), suggesting that the coat is predominantly composed of lipoproteins. In the present study, evidence is presented that heparin, when administered intravenously in goats, potentiated both the translocation of the surface-coat into the vacuolar system and the expansion of the Golgi apparatus. Sequentially, these changes were followed by proliferation of peroxisomes in combination with peroxisomal reticulum (PR), a transient precursor of this organelle. The peroxisomes, as well as PR, reacted positively for catalase after aldehyde fixation and 3,3'-diaminobenzidine (DAB) staining. In addition to their role as phagocytes, the ultrastructural and cytochemical detection of peroxisomes suggests a functional capacity of the PIMs, which may be adaptable to the circulating level of free fatty acids (FAAs).
Onkar S Atwal; Carol S Williams; Kanwal J Minhas; Mohinder S Nijjar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Anatomical record     Volume:  266     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-18     Completed Date:  2002-02-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-80     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
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MeSH Terms
Catalase / analysis,  metabolism
Cell Membrane / drug effects,  ultrastructure
Golgi Apparatus / drug effects,  ultrastructure
Heparin / administration & dosage,  pharmacology*
Injections, Intravenous
Lung / cytology,  drug effects*
Macrophages, Alveolar / drug effects*,  ultrastructure
Peroxisome Proliferators / administration & dosage,  pharmacology*
Peroxisomes / drug effects*,  enzymology,  ultrastructure
Grant Support
Reg. No./Substance:
0/Peroxisome Proliferators; 9005-49-6/Heparin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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