| In situ heparin-induced peroxisomal reticulum and biogenesis of peroxisomes in pulmonary intravascular macrophages (PIMs) of caprine lung: an ultrastructural and cytochemical study. | |
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MedLine Citation:
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PMID: 11748573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary intravascular macrophages (PIMs) contain a unique electron-dense globular surface-coat which is sensitive to heparin treatment, halothane anesthesia, and the digestive effect of lipolytic lipase (LPL), suggesting that the coat is predominantly composed of lipoproteins. In the present study, evidence is presented that heparin, when administered intravenously in goats, potentiated both the translocation of the surface-coat into the vacuolar system and the expansion of the Golgi apparatus. Sequentially, these changes were followed by proliferation of peroxisomes in combination with peroxisomal reticulum (PR), a transient precursor of this organelle. The peroxisomes, as well as PR, reacted positively for catalase after aldehyde fixation and 3,3'-diaminobenzidine (DAB) staining. In addition to their role as phagocytes, the ultrastructural and cytochemical detection of peroxisomes suggests a functional capacity of the PIMs, which may be adaptable to the circulating level of free fatty acids (FAAs). |
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Authors:
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Onkar S Atwal; Carol S Williams; Kanwal J Minhas; Mohinder S Nijjar |
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10377303 - Anticoagulation in pregnant women with mechanical heart valve prostheses. 11156153 - Cardiopulmonary bypass in patients with heparin-induced thrombocytopenia and thrombosis. 21917703 - Maternal diet, c-reactive protein, and the outcome of pregnancy. |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Anatomical record Volume: 266 ISSN: 0003-276X ISO Abbreviation: Anat. Rec. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2001-12-18 Completed Date: 2002-02-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370540 Medline TA: Anat Rec Country: United States |
Other Details:
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Languages: eng Pagination: 69-80 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley-Liss, Inc. |
Affiliation:
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Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada. oatwal@uoguelph.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catalase / analysis, metabolism Cell Membrane / drug effects, ultrastructure Female Goats* Golgi Apparatus / drug effects, ultrastructure Heparin / administration & dosage, pharmacology* Histocytochemistry Injections, Intravenous Lung / cytology, drug effects* Macrophages, Alveolar / drug effects*, ultrastructure Male Peroxisome Proliferators / administration & dosage, pharmacology* Peroxisomes / drug effects*, enzymology, ultrastructure |
| Grant Support | |
ID/Acronym/Agency:
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5-G12RR03059/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peroxisome Proliferators; 9005-49-6/Heparin; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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