Document Detail


In situ-gelling gellan formulations as vehicles for oral drug delivery.
MedLine Citation:
PMID:  10425334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gels formed in situ following oral administration of 1% (w/v) aqueous solutions of gellan to rats and rabbits were evaluated as sustained-release vehicles. The formulation contained calcium ions in complexed form, the release of which in the acidic environment of the stomach caused gelation of the gellan gum. The in vitro release of theophylline from the rigid gellan gels followed root-time kinetics over a period of 6 h. Plasma levels of theophylline after oral administration of gellan solutions and a commercial oral sustained-release liquid dosage form containing an identical drug concentration were compared in both rats and rabbits. Bioavailability of theophylline from gellan gels formed by in situ gelation in the animal stomach was increased by four-fivefold in rats and threefold in rabbits compared with that from the commercial oral formulation. There was no significant difference in the mean residence times of theophylline when administered by these two vehicles.
Authors:
S Miyazaki; H Aoyama; N Kawasaki; W Kubo; D Attwood
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  60     ISSN:  0168-3659     ISO Abbreviation:  J Control Release     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-26     Completed Date:  1999-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  287-95     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Ishikari-Tohbetsu, Hokkaido 061-0293, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Anesthesia
Animals
Biological Availability
Delayed-Action Preparations / pharmacokinetics*
Drug Delivery Systems
Fasting
Male
Polysaccharides, Bacterial / chemistry*
Rabbits
Rats
Rats, Wistar
Species Specificity
Stomach / metabolism*
Theophylline / blood*
Time Factors
Vasodilator Agents / blood
Vehicles / chemistry*
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Polysaccharides, Bacterial; 0/Vasodilator Agents; 0/Vehicles; 58-55-9/Theophylline; 71010-52-1/gellan gum

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