| In situ-gelling, erodible N-isopropylacrylamide copolymers. | |
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MedLine Citation:
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PMID: 15997439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Copolymers of N-isopropylacrylamide, 2-hydroxyethyl methacryl lactate [(HEMA)-lactate] and acrylic acid (AAc) were prepared with varying mole ratios of monomers to develop copolymers with gelation properties above a certain concentration for a bioerodible, in-situ gelling material. The copolymers formed gels in situ under physiological condition. The gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers increased due to the hydrophobicity of HEMA-lactate, and increased as the AAc content increased due to the hydrophilicity of AAc. The gels redissolve at 37 degrees C as their LCSTs increase above 37 degrees C due to the hydrolysis of the HEMA-lactate pendant groups. |
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Authors:
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Bae Hoon Lee; Brent Vernon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Macromolecular bioscience Volume: 5 ISSN: 1616-5187 ISO Abbreviation: Macromol Biosci Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-18 Completed Date: 2005-12-05 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 629-35 Citation Subset: IM |
Affiliation:
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The Harrington Department of Bioengineering, Arizona State University, ECG 334, Tempe, AZ 85287-9709, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylamides
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chemistry* Acrylates / chemistry Biocompatible Materials / chemical synthesis, chemistry* Gels / chemical synthesis, chemistry* Hydrolysis Lactates / chemistry Methacrylates / chemistry Polymers / chemical synthesis, chemistry* Temperature |
| Grant Support | |
ID/Acronym/Agency:
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5R01 GM065917-02/GM/NIGMS NIH HHS; R01 GM065917-01A1/GM/NIGMS NIH HHS; R01 GM065917-02/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acrylamides; 0/Acrylates; 0/Biocompatible Materials; 0/Gels; 0/Lactates; 0/Methacrylates; 0/Polymers; 2210-25-5/N-isopropylacrylamide; 79-10-7/acrylic acid; 868-77-9/hydroxyethyl methacrylate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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