Document Detail

In situ fluoride retention and remineralization of incipient carious lesions after the application of different concentrations of fluoride.
MedLine Citation:
PMID:  19196319     Owner:  NLM     Status:  MEDLINE    
Limited information is available on the time-dependent or dosage-dependent cariostatic efficacy of highly concentrated fluoride compounds. This good clinical practice-conforming, double-blind, placebo-controlled, crossover in situ study tested the hypothesis that a 1.0% amine fluoride fluid is superior to a 0.5% amine fluoride fluid regarding fluoride retention and mineral change in initial caries enamel lesions over a period of 28 d. Fluoride retention was significantly higher after application of the two fluoride fluids compared with placebo but had decreased in both groups to similar levels after only 1 wk. Mineral gain was significantly higher for both verum groups compared with placebo. The use of 1% fluoride fluid resulted in significantly higher remineralization compared with the use of 0.5% fluoride fluid. For both fluoride fluids mineral gain followed a linear relationship with time during the experimental period, indicating a possible further uptake of mineral, even after 4 wk.
Markus J Altenburger; Jörg F Schirrmeister; Adrian Lussi; Manfred Klasser; Elmar Hellwig
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of oral sciences     Volume:  117     ISSN:  1600-0722     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-06     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  58-63     Citation Subset:  D; IM    
Department of Operative Dentistry and Periodontology, University Hospital and Dental School, University of Freiburg, Freiburg, Germany.
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MeSH Terms
Cariostatic Agents / administration & dosage*
Cross-Over Studies
Dental Caries / prevention & control*
Dental Enamel / drug effects*,  metabolism
Dose-Response Relationship, Drug
Double-Blind Method
Fluorides, Topical / administration & dosage*,  pharmacokinetics
Middle Aged
Tooth Remineralization / methods*
Tooth, Artificial
Young Adult
Reg. No./Substance:
0/Cariostatic Agents; 0/Fluorides, Topical; 0/amine fluoride solution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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