Document Detail

In situ expression of CD23 in lymph nodes of patients with Kimura's disease.
MedLine Citation:
PMID:  21216546     Owner:  NLM     Status:  Publisher    
OBJECTIVE: The aim of this study was to investigate the expression of CD23 (Fcɛ RII) in the lymph nodes (LNs) of patients with Kimura's disease (KD). METHODS: Expression of CD23 was examined immunohistochemically. The concentrations of soluble CD23 and titers of IgE in sera from patients with KD were studied by enzyme-linked immunosorbent assay (ELISA). RESULTS: In the germinal centers (GCs) of LNs from patients with KD, overexpression of CD23 on well-developed follicular dendritic cells (FDCs) was observed. GC lymphocytes in the LNs of KD patients were intensely positive for CD23, and positive cells were also observed in both the light and dark zones. In contrast, in the LNs of normal patients, CD23-positive cells were restricted to the light zone of the GCs. Although serum IgE titers were raised in all KD patients, serum concentrations of soluble CD23 were not elevated. CONCLUSION: These results suggest that CD23 and FDCs play important roles in the pathogenesis of KD.
Naoko Akatsuka; Nobuo Ohta; Shigeru Fukase; Masaru Aoyagi; Mitsunori Yamakawa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-7
Journal Detail:
Title:  Auris, nasus, larynx     Volume:  -     ISSN:  1879-1476     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708170     Medline TA:  Auris Nasus Larynx     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier Ireland Ltd.
Department of Otorhinolaryngology, Yamagata University Faculty of Medicine, 2-2-2, Iida-nishi, Yamagata 990-9585, Japan.
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