| In situ detection of prolactin receptor mRNA and apoptotic cell death in mouse uterine tissues with adenomyosis. | |
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MedLine Citation:
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PMID: 10218134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prolactin receptor (PRLR) mRNA was visualized by in situ hybridization in adenomyotic uteri of mice with ectopic pituitary grafting. The signals of PRLR mRNA were mainly detected in the smooth muscle cells of myometrium and the epithelial cells of uterine glands and lumen. In the uteri with adenomyosis, the expression intensity was stronger than that in the normal uteri of control mice. This might reflect the higher serum prolactin (PRL) levels in the mouse with pituitary graft, as reported previously. Electron microscopic observation showed that apoptotic cell death occurred in certain cells in the myometrium bearing adenomyotic changes. Such changes were rarely observed in the normal uteri. The relevance of these findings to the development of adenomyosis was examined. |
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Authors:
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M Yamashita; M Matsuda; T Mori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: In vivo (Athens, Greece) Volume: 13 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 1999 Jan-Feb |
Date Detail:
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Created Date: 1999-06-28 Completed Date: 1999-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8806809 Medline TA: In Vivo Country: GREECE |
Other Details:
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Languages: eng Pagination: 57-60 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Endometriosis / metabolism*, pathology Female In Situ Hybridization Mice Myometrium / metabolism, pathology RNA, Messenger Receptors, Prolactin / genetics* Uterus / metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Receptors, Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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