| In situ cardiac function in Atlantic cod (Gadus morhua): effects of acute and chronic hypoxia. | |
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MedLine Citation:
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PMID: 20154198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent in vivo experiments on Atlantic cod (Gadus morhua) acclimated to chronic hypoxia (6-12 weeks at 10 degrees C; Pw(O(2)) approximately 8-9 kPa) revealed a considerable decrease in the pumping capacity of the heart. To examine whether this diminished cardiac performance was due to the direct effects of chronic moderate hypoxia on the myocardium (as opposed to alterations in neural and/or hormonal control), we measured the resting and maximum in situ function of hearts from normoxia- and hypoxia-acclimated cod: (1) when initially perfused with oxygenated saline; (2) at the end of a 15 min exposure to severe hypoxia (P(O(2)) approximately 0.6 kPa); and (3) 30 min after the hearts had been reperfused with oxygenated saline. Acclimation to hypoxia did not influence resting (basal) in situ cardiac performance during oxygenated or hypoxic conditions. However, it caused a decrease in maximum cardiac output (Q(max)) under oxygenated conditions (from 49.5 to 40.3 ml min(-1) kg(-1); by 19%), that was due to diminished values for maximum stroke volume (V(S)) and scope for V(S). Severe hypoxia reduced in both groups to approximately 20 ml min(-1) kg(-1), yet, the hearts of hypoxia-acclimated fish were better able to sustain this level of Q under hypoxia, and the recovery of Q(max) (as compared with initial values under oxygenated conditions) was significantly improved (94% vs 83%). These data show that acclimation to hypoxia has a direct effect on cod myocardial function and/or physiology, and suggest that the cod heart shows some adaptations to prolonged hypoxia. |
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Authors:
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L H Petersen; A K Gamperl |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of experimental biology Volume: 213 ISSN: 1477-9145 ISO Abbreviation: J. Exp. Biol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-05-03 Revised Date: 2010-05-19 |
Medline Journal Info:
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Nlm Unique ID: 0243705 Medline TA: J Exp Biol Country: England |
Other Details:
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Languages: eng Pagination: 820-30 Citation Subset: IM |
Affiliation:
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Ocean Sciences Centre, Memorial University of Newfoundland, St John's, NL, Canada, A1C 5S7. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization
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physiology Acute Disease Animals Anoxia / physiopathology* Cardiac Output / physiology Chronic Disease Gadus morhua / physiology* Heart / physiopathology* Heart Function Tests* Pressure Rest / physiology |
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