Document Detail

In situ carcinoma of the vocal cords.
MedLine Citation:
PMID:  455229     Owner:  NLM     Status:  MEDLINE    
Eighty-one patients with preinvasive carcinoma of the vocal cord, seen over a thirteen year period, were reviewed histologically and analyzed for response to treatment. Sixty-seven cases were clinically T1 and fourteen cases T2 (by virtue of extension of disease beyond the vocal cord). All patients had mobile cords. Histological criteria for in situ carcinoma and the spectrum of microscopic patterns are presented. Sixty-nine patients were treated by external beam radiotherapy--the remainder by a variety of surgical procedures. Five and ten year actuarial, recurrence-free rates 83% and 75%, respectively for the group treated by irradiation. No difference in local control was observed when analyzed for: 1) dose response, 2) initial extent of disease, 3) treatment plan, or 4) histologic diagnosis. Analysis of failures reveals that 15/17 patients with local failure were salvaged, eleven of these patients requiring laryngectomy. Time to appearance of recurrence ranged from seven to one hundred and seven months.
A J Elman; M Goodman; C C Wang; B Pilch; J Busse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  43     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2422-8     Citation Subset:  AIM; IM    
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MeSH Terms
Carcinoma in Situ / pathology,  therapy*
Carcinoma, Squamous Cell / pathology,  therapy*
Laryngeal Neoplasms / pathology,  therapy*
Middle Aged
Radioisotope Teletherapy
Remission, Spontaneous
Time Factors
Vocal Cords*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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