| In situ gelation of supramolecular hydrogel for anti-tumor drug delivery. | |
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MedLine Citation:
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PMID: 19911347 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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A supramolecular injectable hydrogel was fabricated. The hydrogel was in situ gelated by the host-guest interaction between alpha-cyclodextrins (alpha-CDs) and methylated poly(ethylene glycol) grafted poly(alpha,beta-malic acid) (mPEG-g-PMA). The hydrogel was characterized by (1)NMR, XRD, DSC, TGA and SEM. The results showed that the polyrotaxanes of alpha-CDs/mPEG-g-PMA acted as physical crosslink sites in the hydrogel. Anti-tumor drug doxorubicin hydrochloride (DOX) was loaded in the hydrogel. The release and anti-tumor effect were studied in vitro. The burst release of DOX was restrained obviously. The sustaining release time lasted more than 3 d and the cell viability decreased greatly. This hydrogel is a promising injectable hydrogel for minimally invasive therapeutic drug delivery. |
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Authors:
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Bin He; Jing Zeng; Yu Nie; Li Ji; Rui Wang; Yuan Li; Yao Wu; Li Li; Gang Wang; Xianglin Luo; Zhirong Zhang; Zhongwei Gu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Macromolecular bioscience Volume: 9 ISSN: 1616-5195 ISO Abbreviation: Macromol Biosci Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 1169-75 Citation Subset: IM |
Affiliation:
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National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China. bhe@scu.edu.cn |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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