Document Detail


In silico model of an antenna of a phycobilisome and energy transfer rates determination by theoretical Förster approach.
MedLine Citation:
PMID:  23047609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Energy transfer (ET) in phycobilisomes, a macrocomplex of phycobiliproteins and linker proteins, is a process that is difficult to understand completely. A model for a rod composed of two hexamers of Phycocyanin and two hexamers of Phycoerythrin was built using an in silico approach and the three-dimensional structures of both phycobiliproteins from Gracilaria chilensis. The model was characterized and showed 125 Å wide and 230 Å high, which agree with the dimensions of a piling of four hexamers as observed in the images of subcomplexes of phycobilisomes obtained by transmission electron microscopy. ET rates between every pair of chromophores in the model were calculated using the Förster approach, and the fastest rates were selected to draw preferential ET pathways along the rod. Every path indicates that the ET is funneled toward the chromophores located at Cysteines 82 in Phycoerythrin and 84 in Phycocyanin. The chromophores that face the exterior of the rod are phycoerythrobilins, and they also show a preferential ET toward the chromophores located at the center of the rod. The values calculated, in general, agree with the experimental data reported previously, which validates the use of this experimental approach.
Authors:
Maximiliano Figueroa; José Martínez-Oyanedel; Adelio R Matamala; Jorge Dagnino-Leone; Claudia Mella; Rubén Fritz; José Sepúlveda-Ugarte; Marta Bunster
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-06
Journal Detail:
Title:  Protein science : a publication of the Protein Society     Volume:  21     ISSN:  1469-896X     ISO Abbreviation:  Protein Sci.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-27     Completed Date:  2013-04-29     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  9211750     Medline TA:  Protein Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1921-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 The Protein Society.
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MeSH Terms
Descriptor/Qualifier:
Computer Simulation
Energy Transfer
Gracilaria / chemistry*,  metabolism
Models, Molecular
Phycocyanin / chemistry*,  metabolism
Phycoerythrin / chemistry*,  metabolism
Plant Proteins / chemistry*,  metabolism
Protein Multimerization
Chemical
Reg. No./Substance:
0/Plant Proteins; 11016-15-2/Phycocyanin; 11016-17-4/Phycoerythrin
Comments/Corrections

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