Document Detail


In silico assessment of toxicity of heat-generated food contaminants.
MedLine Citation:
PMID:  18334278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since the discovery of acrylamide in heat-treated carbohydrate-rich foods, many more heat-generated food contaminants have been identified in a variety of foods and models systems. A database of these contaminants, generated as a result of either lipid oxidation or the Maillard reaction, has recently been compiled under the HEATOX project. A large majority of the compounds has not been tested for potential adverse effects on human health, which makes it difficult to carry out adequate assessment of risks to an average consumer. This study used two in silico toxicity Expert Systems (Topkat and Derek for Windows), as a preliminary screening tool to identify potential toxicants among the heat-generated contaminants in foods or model systems. The methodology enabled prioritisation of the compounds on the basis of predicted toxicities, and identification of potential toxicants for targeted testing by standard laboratory procedures. A comparison between the predicted toxicities of selected compounds and the available experimental data indicated that the methodology can be reliably used for assessing toxicity of untested food contaminants.
Authors:
J V Cotterill; M Q Chaudhry; W Matthews; R W Watkins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-26
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-07-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1905-18     Citation Subset:  IM    
Affiliation:
Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK. j.cotterill@csl.gov.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogenicity Tests
Carcinogens / toxicity
Computer Simulation
Cookery*
Expert Systems
Food Contamination / analysis*
Hot Temperature
Lethal Dose 50
Mutagenicity Tests
Mutagens / toxicity
Rats
Toxicity Tests / methods*
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Mutagens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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