Document Detail

In search of new neuromuscular blocking drugs with quick onset and short duration of effect.
MedLine Citation:
PMID:  8082688     Owner:  NLM     Status:  MEDLINE    
In experiments using cats the neuromuscular blocking effect of bis-trimethylammonium derivatives having a non-depolarizing mode of action had an onset of action shorter than that of their triethylammonium analogs. The difference in equieffective doses of neuromuscular blocking agents administered intravenously or intraarterially was less in the case of compounds with rigid molecules than that with flexible molecules. Results indicate that a more considerable portion of flexible substance absorbs on the 'site of loss' in blood vessels than for rigid compounds. This suggests that rigid molecules promote a faster achievement of effective concentration of a neuromuscular blocking agent at synapses. Proceeding from these data a bis-trimethylammonium derivative with a rigid molecule, IEM-1213, was synthesized and studied in cats.
A F Danilov; V E Gmiro; D J Fedorov
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  257     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-10     Completed Date:  1994-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St.-Petersburg.
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MeSH Terms
Bis-Trimethylammonium Compounds / chemical synthesis,  chemistry,  pharmacology*
Injections, Intra-Arterial
Injections, Intravenous
Muscle Relaxation / drug effects
Muscles / drug effects*
Neuromuscular Nondepolarizing Agents / administration & dosage,  chemistry,  pharmacology*
Reg. No./Substance:
0/Bis-Trimethylammonium Compounds; 0/IEM 1213; 0/Neuromuscular Nondepolarizing Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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