| In search of lost trajectories: Recovering the diversification of transposable elements. | |
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MedLine Citation:
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PMID: 22016865 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Transposable elements (TEs) are DNA sequences that have the capacity to move and duplicate within genomes, and occasionally between them. They are present in almost all species and are especially prevalent in eukaryotes where they can account for most of the genomic content. As a result of their dynamics and their mere presence, TEs can profoundly shape genomes and gene expression. With the current pace of sequencing technology improvement, a rapidly increasing number of genomes, particularly from non-model species, are being sequenced. However, the complete annotation of these genomes and especially of the TEs they contain, still poses fundamental difficulties. In a recent article, we presented a combined method that automatically annotates TEs with accuracy and sensitivity, and takes their diversification dynamics into account in the de novo annotation process. Here, we further discuss several additional aspects of our results, notably in the light of our knowledge of TE dynamics and the conceptual model behind the TE detection algorithms currently in use. In addition, we propose a new approach that uses simulations to improve algorithm performance. |
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Authors:
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Timothée Flutre; Emmanuelle Permal; Hadi Quesneville |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-1 |
Journal Detail:
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Title: Mobile genetic elements Volume: 1 ISSN: 2159-256X ISO Abbreviation: - Publication Date: 2011 7 |
Date Detail:
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Created Date: 2011-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101564504 Medline TA: Mob Genet Elements Country: - |
Other Details:
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Languages: ENG Pagination: 151-154 Citation Subset: - |
Affiliation:
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Unité de Recherche en Génomique-Info; UR 1164; INRA Centre de Versailles-Grignon; Versailles, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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