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In search of the determinants of enhancer-promoter interaction specificity.
MedLine Citation:
PMID:  25160912     Owner:  NLM     Status:  Publisher    
Although it was originally believed that enhancers activate only the nearest promoter, recent global analyses enabled by high-throughput technology suggest that the network of enhancer-promoter interactions is far more complex. The mechanisms that determine the specificity of enhancer-promoter interactions are still poorly understood, but they are thought to include biochemical compatibility, constraints imposed by the three-dimensional architecture of chromosomes, insulator elements, and possibly the effects of local chromatin composition. In this review, we assess the current insights into these determinants, and highlight the functional genomic approaches that will lead the way towards better mechanistic understanding.
Joris van Arensbergen; Bas van Steensel; Harmen J Bussemaker
Publication Detail:
Type:  REVIEW     Date:  2014-8-23
Journal Detail:
Title:  Trends in cell biology     Volume:  -     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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