Document Detail

In quest of thyroid hormone function in mature mammalian brain.
MedLine Citation:
PMID:  12597014     Owner:  NLM     Status:  MEDLINE    
Thyroid hormones (TH) have important functions in maturation, differentiation and metabolism during developmental periods in almost all types of tissues including brain of vertebrate animals. In humans' thyroid malfunction in early developmental stages cause severe neuropsychological abnormalities due to defective gene expression via nuclear receptor activation. However, role of TH in adult mammalian brain is lacking and unclear mainly because it was considered for a long time as a TH unresponsive tissue. Although adult brain contains a substantial number of TH nuclear receptors, no functional properties could be attributed. Recent findings suggest that T3 is distributed, concentrated, metabolized and binds to specific membrane sites within adult brain. In mature humans TH also reversibly regulates various neuropsychological symptoms produced in mature condition. This review discusses development of recent concepts and literature on role of TH and its importance in neuronal function in adult mammalian brain.
Pradip K Sarkar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  40     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-04-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  865-73     Citation Subset:  IM    
Department of Biology, Rutgers University, Camden, New Jersey 08102, USA.
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MeSH Terms
Brain / physiology*
Receptors, Thyroid Hormone / metabolism
Thyroid Hormones / physiology*
Reg. No./Substance:
0/Receptors, Thyroid Hormone; 0/Thyroid Hormones

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