| In patients with hypertrophic cardiomyopathy myocardial fibrosis is associated with both left ventricular and left atrial dysfunction. | |
| | |
MedLine Citation:
|
PMID: 22641976 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
AIMS: The aim of this study was to assess LA function by two-dimensional speckle-tracking echocardiography and its relation with myocardial fibrosis in hypertrophic cardiomyopathy (HCM). METHODS: We enrolled 30 consecutive HCM-patients in our study (20 males; age: 49.7 +/- 10.4 years, NYHA-class: 1.9 +/- 0.7). Echocardiography was performed with assessment of global longitudinal LV strain (epsilon) and LA epsilon and strain-rate parameters (systolic, early diastolic, and late diastolic during atrial contraction). Each patient received delayed-enhancement magnetic resonance imaging (DE-MRI) to check for myocardial fibrosis. We divided the patients into two groups. Patients of group 1 had no fibrosis, group 2 demonstrated moderate or severe fibrosis in > or = 2 segments using a 17 segment-model of the LV. RESULTS: Moderate and severe fibrosis was observed in 20 patients (group 2: 66.7%). Global longitudinal LV epsilon (-13.0 +/- 2.4 vs -20.6 +/- 3.2%, P < 0.001) and peak LA epsilon (-0.2 +/- 3.9 vs 17.9 +/- 6.7%, P < 0.001) were reduced in group 2 in comparison with patients without myocardial fibrosis. In all patients peak LA epsilon correlated with global longitudinal LV epsilon (r = -0.78, P < 0.001). Patients with considerable myocardial fibrosis (group 2) had a higher indexed left atrial volume (35.7 +/- 12.8 ml/m2 vs 24.1 +/- 8.6 ml/m2, P = 0.016). New York Heart Association class (NYHA) was higher in patients with severe myocardial fibrosis (2.2 +/- 0.7 vs 1.3 +/- 0.5) and correlated with peak LA (r = -0.5, P = 0.008) and global LV epsilon (r = 0.5, P = 0.005). CONCLUSIONS: Occurrence of myocardial fibrosis in hypertrophic cardiomyopathy is associated with left atrial and ventricular dysfunction as well as with the severity of heart failure symptoms. |
| | |
Authors:
|
Christian Prinz; Frank Van Buuren; Nicola Bogunovic; Thomas Bitter; Lothar Faber; Dieter Horstkotte |
Related Documents
:
|
21511066 - Consideration of qrs complex in addition to st-segment abnormalities in the estimated "... 5723386 - Report of 24 cases of myocardial infarction treated at home. 22021246 - Carriers of the hypertrophic cardiomyopathy mybpc3 mutation are characterized by reduce... 22113206 - Subclinical myocardial dysfunction in rett syndrome. 23760446 - Transcriptional profiling of hmgb1-induced myocardial repair identifies a key role for ... 22473026 - Impact of altitude on predicting midterm outcome in patients with st elevation myocardi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta cardiologica Volume: 67 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-05-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
|
Languages: eng Pagination: 187-93 Citation Subset: IM |
Affiliation:
|
Dept. of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany. Cchrprinz@aol.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanical ventilation with positive end-expiratory pressure in critically ill patients: comparison ...
Next Document: Relation of the metabolic syndrome with proarrhythmogenic electrocardiographic parameters in patient...