Document Detail

In patients with hypertensive left ventricular hypertrophy and coronary heart disease, coronary flow reserve is similarly impaired.
MedLine Citation:
PMID:  8580484     Owner:  NLM     Status:  MEDLINE    
Coronary blood flow reserve (CFR) was assessed by transesophageal Doppler echocardiography in normal subjects (group A, n = 20), hypertensive non-left ventricular hypertrophy (non-LVH) patients (group B, n = 22), hypertensive patients with LVH (group C, n = 32) and coronary heart disease patients (group D, n = 33) with the volume sample placed at the bifurcation of the left main and left descending coronary artery. Coronary blood flow velocity (CBFV) was evaluated at rest, 2 minutes after dipyridamole (0.56 mg/kg, i.v.), and 2 minutes after aminophylline i.v. The ratio of dipyridamole to rest maximal diastolic velocity (D/R PDV) was considered the index of coronary blood flow reserve. It was found that D/R PDV was significantly less in groups C and D compared with that in groups A and B(D/R PDV, 1.84 +/- 0.57, 1.57 +/- 0.41 versus 2.59 +/- 0.70 and 2.22 +/- 0.58, respectively), with no difference in D/R PDV between groups C and D. Twenty-four out of 32 patients in group C with D/R PDV were less than 2.0 compared to 29 out of 33 patients in group D (P > 0.05). Significant negative correlation was found between D/R PDV, D/R PSV and interseptal thickness, left ventricular mass index in hypertensive patients. These data show that impaired CFR in hypertensive patients with LVH is comparable to that in patients with coronary heart disease.
D Chen; J Lin; J Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  10     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Department of Medicine, First Affiliated Hospital of Fujian Medical College, Fuzhou.
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MeSH Terms
Aminophylline / pharmacology
Blood Flow Velocity
Cardiotonic Agents / pharmacology
Coronary Circulation / drug effects*
Coronary Disease / physiopathology*,  ultrasonography
Dipyridamole / pharmacology
Echocardiography, Transesophageal
Hypertension / complications*
Hypertrophy, Left Ventricular / physiopathology*,  ultrasonography
Middle Aged
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Cardiotonic Agents; 0/Vasodilator Agents; 317-34-0/Aminophylline; 58-32-2/Dipyridamole

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