Document Detail

In- and outpatients with noncompaction: differences in cardiac and neuromuscular co-morbidity.
MedLine Citation:
PMID:  19095319     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND METHODS: The prognosis of patients with left ventricular hypertrabeculation/noncompaction (LVHT) is controversial. LVHT is associated with neuromuscular disorders (NMD) and diagnosed echocardiographically in in- as well as outpatients. We compared cardiologic and neurologic findings and mortality in LVHT-patients according to their diagnosis established as in- or outpatients. RESULTS: Among 113 patients (33 females, mean-age 53 years), 91 were investigated neurologically. Fifty-nine inpatients were older (55 versus 50 years, p<0.05), more frequently referred because of heart failure (73 versus 37%, p<0.001), had more often diabetes (24 versus 7%, p<0.05), heart failure (81 versus 57%, p<0.01), a lower left-ventricular fractional-shortening (21 versus 26%, p<0.05) and more extensive LVHT (1.7 versus 1.5 affected walls, p<0.05). Fifty-four outpatients were referred more often because of chest-pain (33 versus 12%, p<0.01), myopathy (13 versus 2%, p<0.05), were more often neurologically normal (20 versus 7%, p<0.05) or had a specific NMD (28 versus 12%, p<0.05). During a mean follow-up of 3.8 years, mortality was 5.8%/year. Inpatients had a higher mortality (12.1 versus 2.1%/year, p=0.0002) and a shorter time between LVHT-diagnosis and death (1.7 versus 4.6 years, p=0.0197) than outpatients. CONCLUSIONS: Outpatients with LVHT have a better prognosis than inpatients. Inpatients with LVHT should be closely monitored.
Claudia St?llberger; Gerhard Blazek; Maria Winkler-Dworak; Josef Finsterer
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Publication Detail:
Type:  Letter     Date:  2008-12-17
Journal Detail:
Title:  International journal of cardiology     Volume:  140     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  108-11     Citation Subset:  IM    
Copyright Information:
Copyright 2008. Published by Elsevier Ireland Ltd.
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MeSH Terms
Aged, 80 and over
Ambulatory Care
Chest Pain / pathology*
Heart Diseases / epidemiology*,  pathology
Heart Failure / pathology*
Heart Ventricles / pathology*
Middle Aged
Myocardium / pathology*
Neuromuscular Diseases / epidemiology*,  pathology
Young Adult

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