Document Detail


In neuroblastic tumours, Schwann cells do not harbour the genetic alterations of neuroblasts but may nevertheless share the same clonal origin.
MedLine Citation:
PMID:  18071318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuroblastic tumours are composed of variable proportions of neuroblasts and Schwann cells. Whether both components share a common neoplastic origin is highly debated and discrepant results have been reported about the presence of tumour-related genetic alterations in Schwann cells. We have used X-methylation analysis and array-CGH to investigate contiguous Schwannian and neuroblastic areas in tumours with a nodular pattern. A skewed X inactivation was observed in four out of five stromal components. Interestingly, in these four cases, the X-inactivation profiles of the neuroblastic components were identical to the matched stromal areas. However, whereas all neuroblastic areas displayed chromosomal imbalances, no alteration was found in any Schwann cell components. Similarly, no alteration was observed in a series of 19 tumours with a single stroma-rich component, which occasionally exhibited a skewed X-inactivation pattern (3/17 informative tumours). Altogether, this indicates that most stroma-rich tumours display a polyclonal proliferation and that Schwann cells do not derive from neuroblasts. However, in tumours with both stroma-rich and -poor components, our results suggest that cells from both areas share a common progenitor.
Authors:
F Bourdeaut; A Ribeiro; R Paris; G Pierron; J Couturier; M Peuchmaur; O Delattre
Related Documents :
7374758 - Saccharin may act as a tumour promoter by inhibiting metabolic cooperation between cells.
1212418 - The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. impl...
186418 - Studies on the microcytotoxicity test. i. evidence that the effects of normal lymphoid ...
17078868 - Suppression of breast cancer cell growth by na+/h+ exchanger regulatory factor 1 (nherf1).
22825748 - In vitro proliferation and differentiation of adipose-derived stem cells isolated using...
22992568 - Gene expression of vitamin d metabolic enzymes at baseline and in response to vitamin d...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-10
Journal Detail:
Title:  Oncogene     Volume:  27     ISSN:  1476-5594     ISO Abbreviation:  Oncogene     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-08     Completed Date:  2008-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  3066-71     Citation Subset:  IM    
Affiliation:
INSERM, U830, Section de Recherche, Unité de Génétique et Biologie des Cancers, Institut Curie, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Differentiation
DNA Methylation
Humans
Neuroblastoma / genetics*,  pathology
Schwann Cells / pathology*
X Chromosome Inactivation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human canc...
Next Document:  Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer.