Document Detail

In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome.
MedLine Citation:
PMID:  21793823     Owner:  NLM     Status:  Publisher    
Eur J Clin Invest 2011 ABSTRACT: Background  Central sensitisation entails several top-down and bottom-up mechanisms, all contributing to the hyperresponsiveness of the central nervous system to a variety of inputs. In the late nineties, it was first hypothesised that chronic fatigue syndrome (CFS) is characterised by hypersensitivity of the central nervous system (i.e. central sensitisation). Since then, several studies have examined central sensitisation in patients with CFS. This study provides an overview of such studies. Materials and Methods  Narrative review. Results  Various studies showed generalised hyperalgesia in CFS for a variety of sensory stimuli, including electrical stimulation, mechanical pressure, heat and histamine. Various tissues are affected by generalised hyperalgesia: the skin, muscle tissue and the lungs. Generalised hyperalgesia in CFS is augmented, rather than decreased, following various types of stressors like exercise and noxious heat pain. Endogenous inhibition is not activated in response to exercise and activation of diffuse noxious inhibitory controls following noxious heat application to the skin is delayed. Conclusions  The observation of central sensitisation in CFS is in line with our current understanding of CFS. The presence of central sensitisation in CFS corroborates with the presence of several psychological influences on the illness, the presence of infectious agents and immune dysfunctions and the dysfunctional hypothalamus-pituitary-adrenal axis as seen in these severely debilitated patients.
Jo Nijs; Mira Meeus; Jessica Van Oosterwijck; Kelly Ickmans; Greta Moorkens; Guy Hans; Luc S De Clerck
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-2
Journal Detail:
Title:  European journal of clinical investigation     Volume:  -     ISSN:  1365-2362     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.
Department of Human Physiology, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel (VUB), Brussels, Belgium Division of Musculoskeletal Physiotherapy, Department of Health Care Sciences, Artesis University College Antwerp, Antwerp, Belgium Department of Physical Medicine and Physiotherapy, University Hospital Brussels (UZB), Brussels, Belgium Reference Centre for Chronic Fatigue Syndrome, Department of Internal Medicine, University Hospital Antwerp, Antwerp, Belgium Multidisciplinary Pain Center (PCT), University Hospital Antwerp (UZA), Antwerp, Belgium Department of Immunology, Allergy and Rheumatology, University of Antwerp (UA), Antwerp, Belgium.
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