Document Detail

In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice.
MedLine Citation:
PMID:  21083649     Owner:  NLM     Status:  In-Data-Review    
Aim:  Plasma interleukin-6 (IL-6) increases during exercise by release from active muscles and during prolonged exercise also from the brain. The IL-6 release from muscles continues into recovery and we tested whether the brain also releases IL-6 in recovery from prolonged exercise in humans. Additionally, it was evaluated in mice whether brain release of IL-6 reflected enhanced IL-6 mRNA expression in the brain as modulated by brain glycogen levels. Methods:  Nine healthy male subjects completed 4 h of ergometer rowing while the arterio-jugular venous difference (a-v diff) for IL-6 was determined. The IL-6 mRNA and the glycogen content were determined in mouse hippocampus, cerebellum and cortex before and after 2 h treadmill running (N = 8). Results:  At rest, the IL-6 a-v diff was negligible but decreased to -2.2 ± 1.9 pg ml(-1) at the end of exercise and remained low (-2.1 ± 2.1 pg ml(-1) ) 1 h into the recovery (P < 0.05 vs. rest). IL-6 mRNA was expressed in the three parts of the brain with the lowest content in the hippocampus (P < 0.05) coupled to the highest glycogen content (3.2 ± 0.8 mmol kg(-1) ). Treadmill running increased the hippocampal IL-6 mRNA content 2-3-fold (P < 0.05), while the hippocampal glycogen content decreased to 2.6 ± 0.6 mmol kg(-1) (P < 0.05) with no significant changes in the two other parts of the brain. Conclusion:  Human brain releases IL-6 both during and in recovery from prolonged exercise and mouse data suggest that concurrent changes in IL-6 mRNA and glycogen levels make the hippocampus a likely source of the IL-6 release from the brain.
P Rasmussen; J-C Vedel; J Olesen; H Adser; M V Pedersen; E Hart; N H Secher; H Pilegaard
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Publication Detail:
Type:  Journal Article     Date:  2010-12-08
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  201     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  475-82     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Acta Physiologica © 2010 Scandinavian Physiological Society.
Department of Anesthesia, Department of Biology, University of Copenhagen, Copenhagen, Denmark  Copenhagen Muscle Research Centre, and Department of Biology, University of Copenhagen, Copenhagen, Denmark  Zurich Centre for Integrative Human Physiology, University of Zurich, Switzerland  Centre of Inflammation and Metabolism, Department of Biology, University of Copenhagen, Copenhagen, Denmark  Centre for Sports Medicine and Human Performance, Brunel University, UK.
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