| In-hospital and one year outcomes with drug-eluting versus bare-metal stents in large native coronary arteries a report from the evaluation of drug-eluting stents and ischemic events (EVENT) registry. | |
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MedLine Citation:
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PMID: 22511502 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to compare the clinical outcomes after perctuaneous coronary revascularization of large coronary arteries using drug-eluting (DES) or bare-metal (BMS) stents. BACKGROUND: In de novo native coronary lesions with reference diameters of 2.5-3.5 mm, DES reduce target lesion revascularization (TLR) with no increase in death or myocardial infarction (MI). The relative efficacy of DES in larger coronary artery lesions is less certain. METHODS: From the prospective EVENT registry, we identified patients undergoing stenting of de novo lesions in native coronary arteries 3.5 to 5.0 mm in diameter (n=1485). In-hospital and one year clinical outcomes were compared for BMS (n=282) and DES (n=1203) patients, using propensity stratification to adjust for differences in potential confounding factors. RESULTS: Most patient characteristics were similar for the 2 groups, but BMS patients were more likely to have been treated in the setting of ST elevation MI, whereas DES patients had more bifurcation lesions, smaller vessels, and longer total stent lengths. In risk-adjusted analyses the composite endpoint of 1-year death, MI or target lesion revascularization was similar for BMS and DES (standardized rate: 11.9% vs. 8.5%, p=0.10). DES was associated with a 62% reduction in the risk of TLR, although the absolute difference in event rates was small (standardized rates 4.6% vs. 1.8%, p=0.016). CONCLUSIONS: Among relatively unselected patients undergoing PCI of large native coronary arteries, use of DES was associated with a modest reduction in rates of TLR, with a neutral effect on other ischemic endpoints. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Paul C Gordon; David J Cohen; Neal S Kleiman; Jay A Montgomery; Christopher A Semder; Kevin F Kennedy; Michelle J Keyes; Robert N Piana; |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-18 |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: - ISSN: 1522-726X ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Division of Cardiology, The Miriam Hospital, Providence, Rhode Island. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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