Document Detail

In hamsters dopamine D2 receptors affect ventilation during and following intermittent hypoxia.
MedLine Citation:
PMID:  17884646     Owner:  NLM     Status:  MEDLINE    
We tested the hypothesis that in golden Syrian hamsters (Mesocricetus auratus) carotid body dopaminergic D2 receptors modulate ventilation in air, during exposure to intermittent hypoxia (IH) and reoxygenation. Ventilation was evaluated using the barometric method and CO2 production was determined using the flow through method. Hamsters (n=8) received either subcutaneous injections of vehicle, haloperidol (0.5 mg/kg) or domperidone (0.5 mg/kg). Ventilatory and metabolic variables were determined 30 min following injections, after each of 5 bouts of 5 min of 10% oxygen interspersed by normoxia (IH), and 15, 30, 45 and 60 min following IH when hamsters were exposed to air. Haloperidol, but not domperidone decreased body temperature in hamsters. Neither treatment affected CO2 production. Vehicle-treated hamsters exhibited ventilatory long-term facilitation (VLTF) following IH. Haloperidol or domperidone decreased ventilation in air, during IH and eliminated VLTF due to changes in tidal volume and not frequency of breathing. Thus, in hamsters D2 receptors are involved in control of body temperature and ventilation during and following IH.
Evelyn H Schlenker
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2007-08-28
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  148     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-02     Completed Date:  2007-11-20     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  674-80     Citation Subset:  IM    
Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 East Clark St., Vermillion, SD 57069, USA.
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MeSH Terms
Anoxia / metabolism*,  physiopathology
Body Temperature / drug effects
Carbon Dioxide / metabolism
Carotid Body / drug effects*,  metabolism
Disease Models, Animal
Domperidone / pharmacology*
Dopamine Antagonists / pharmacology*
Haloperidol / pharmacology*
Pulmonary Ventilation / drug effects*
Receptors, Dopamine D2 / antagonists & inhibitors*,  metabolism
Tidal Volume / drug effects
Time Factors
Grant Support
P20 RR-015567/RR/NCRR NIH HHS; P20 RR015567-060003/RR/NCRR NIH HHS
Reg. No./Substance:
0/Dopamine Antagonists; 0/Receptors, Dopamine D2; 124-38-9/Carbon Dioxide; 52-86-8/Haloperidol; 57808-66-9/Domperidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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