Document Detail


In erosive hand osteoarthritis more inflammatory signs on ultrasound are found than in the rest of hand osteoarthritis.
MedLine Citation:
PMID:  22820060     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare inflammation as assessed by ultrasound between patients with the subset erosive hand osteoarthritis (EOA) versus non-EOA.
METHODS: Consecutive hand osteoarthritis (HOA) patients (fulfilling ACR criteria) were included. Eighteen interphalangeal joints were scored on radiographs using the Verbruggen-Veys anatomical phase score; E and R phases were defined as erosive. Patients were assigned to EOA when at least one joint was erosive. Effusion, synovial thickening and power Doppler signal (PDS) were scored with ultrasound on a 4-point scale. Generalised estimated equation analyses were used to compare ultrasound features between EOA and HOA, and to associate ultrasound features with.anatomical phases; OR with 95% CI were calculated with adjustments for patient effects and confounders.
RESULTS: Of 55 HOA patients (mean age 61 years, 86% women) 51% had EOA. In 94 erosive joints, synovial thickening, effusion and PDS were found in 13%, 50% and 15%, respectively; in 896 non-erosive joints in 10%, 26% and 8%, respectively. In summated scores of PDS, effusion was higher in EOA than in non-EOA. Effusion and synovial thickening were more frequent in S, J, E and R phases compared to N phase. PDS was only associated with E phase (OR 5.3, 95% CI 1.3 to 20.5) not with other phases. Non-erosive joints in EOA demonstrated more PDS (OR 3.2, 95% CI 1.6 to 6.4) and effusion (OR 2.2, 95% CI 1.2 to 3.8) in comparison to joints in non-EOA.
CONCLUSIONS: Inflammatory signs are more frequent in EOA than in non-EOA, not only in erosive joints but also in non-erosive joints, suggesting an underlying systemic cause for erosive evolution.
Authors:
Marion C Kortekaas; Wing-Yee Kwok; Monique Reijnierse; Tom W J Huizinga; Margreet Kloppenburg
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-07-20
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  72     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-07-12     Revised Date:  2013-11-12    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  930-4     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. m.c.kortekaas@lumc.nl
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MeSH Terms
Descriptor/Qualifier:
Aged
Cohort Studies
Female
Finger Joint / ultrasonography*
Humans
Inflammation / ultrasonography
Male
Middle Aged
Osteoarthritis / classification,  complications,  ultrasonography*
Osteophyte / etiology,  ultrasonography
Synovitis / etiology,  ultrasonography*
Ultrasonography, Doppler
Comments/Corrections
Comment In:
Ann Rheum Dis. 2013 Nov 1;72(11):e26   [PMID:  23873878 ]

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