Document Detail

In the beginning: Generating neural crest cell diversity.
MedLine Citation:
PMID:  20930541     Owner:  NLM     Status:  MEDLINE    
Neural crest cells (NCCs) are migratory cells that delaminate from the neural tube early in development and then disseminate throughout the embryo to give rise to a wide variety of cell types that are key to the vertebrate body plan. During their journey from the neural tube to their peripheral targets, NCCs progressively differentiate, raising the question when the fate of an individual NCC is sealed. One hypothesis suggests that the fate of a NCC is specified by target-derived signals emanating from the environment they migrate through, while another hypothesis proposes that NCCs are already specified to differentiate along select lineages at the time they are born in the neural tube, with environmental signals helping them to realize their prespecified fate potential. Alternatively, both mechanisms may cooperate to drive NCC diversity. This review highlights recent advances in our understanding of prespecification during trunk NCC development.
Christiana Ruhrberg; Quenten Schwarz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cell adhesion & migration     Volume:  4     ISSN:  1933-6926     ISO Abbreviation:  Cell Adh Migr     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-06-21     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101469464     Medline TA:  Cell Adh Migr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  622-30     Citation Subset:  IM    
Institute of Opthalmology, University College London.
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MeSH Terms
Abdomen / embryology,  innervation
Autonomic Nervous System / cytology,  embryology
Cell Differentiation*
Cell Movement
Cell Tracking
Ganglia, Sensory / embryology
Intercellular Signaling Peptides and Proteins / metabolism
Neural Crest / cytology*,  embryology
Neuropilins / metabolism
Sensory Receptor Cells / cytology
Signal Transduction
Somites / cytology,  embryology
Thorax / embryology,  innervation
Grant Support
G0600993//Medical Research Council; G0600993//Medical Research Council; G0600993(79144)//Medical Research Council
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 0/Neuropilins

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