Document Detail

In appreciation of Sir Philip Randle: the glucose-fatty acid cycle.
MedLine Citation:
PMID:  17408519     Owner:  NLM     Status:  MEDLINE    
The coordinated regulation of metabolic fuel selection is crucial to energy homeostasis. Philip Randle and his colleagues developed the fundamental concept of interplay between carbohydrate and lipid fuels in relation to the requirement for energy utilisation and storage. Their insight has fashioned current understanding of the regulation of metabolism in health and disease, as well as providing a springboard for research into the roles of lipid derivatives in insulin resistance and, at the transcriptional level, lipid-regulated nuclear hormone receptors.
Mary C Sugden
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Publication Detail:
Type:  Biography; Historical Article; Journal Article; Portraits    
Journal Detail:
Title:  The British journal of nutrition     Volume:  97     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-09-05     Completed Date:  2007-11-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  809-13     Citation Subset:  IM    
Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, Whitechapel, London, UK.
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MeSH Terms
Fatty Acids / history*,  metabolism
Gene Expression
Glucose / history*,  metabolism
History, 20th Century
History, 21st Century
Insulin / history,  metabolism
Insulin Resistance
Lipid Metabolism
Lipids / history
Metabolic Networks and Pathways
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 11061-68-0/Insulin; 50-99-7/Glucose
Personal Name Subject
Personal Name Subject:
Philip Randle

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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