| In angioimmunoblastic T-cell lymphoma, neoplastic T cells may be a minor cell population. A molecular single-cell and immunohistochemical study. | |
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MedLine Citation:
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PMID: 15480765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The significance of T-cell proliferations in angioimmunoblastic lymphoma (AILD) is still enigmatic. Although classified as a malignant T-cell lymphoma in the World Health Organisation lymphoma classification, some cases of AILD lack dominant T-cell clones. In a previous study, based on single-cell polymerase chain reaction (PCR), we obtained similar results as studies of AILD using Southern blot or conventional PCR: some cases of AILD contained large T-cell clones, and, in other cases, T-cell clones were undetectable. As in single-cell studies, only a limited number of cells could be investigated; thus, we wanted to gain more insight into the amount and distribution of tumour cells. By applying triple immunofluorescent staining with antibodies directed against T-cell receptor Vbeta-family-specific epitopes, we investigated T-cell populations in AILD and their localisation in the tissue in relation to B cells (CD20) and follicular dendritic cells (CD21). In two of five cases investigated, only a minority of the T-cells compartment belonged to the tumour clone. Neoplastic T cells were found throughout the tissue, including areas dominated by B cells. |
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Authors:
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Klaus Willenbrock; Christoph Renné; Philippe Gaulard; Martin-Leo Hansmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-10-05 |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 446 ISSN: 0945-6317 ISO Abbreviation: Virchows Arch. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-20 Completed Date: 2005-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 15-20 Citation Subset: IM |
Affiliation:
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Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universität, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany. Willenbrock@em.uni-frankfurt.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD20
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analysis Fluorescent Antibody Technique Humans Immunoblastic Lymphadenopathy / immunology*, pathology Immunohistochemistry Lymphoma, T-Cell / immunology*, pathology Polymerase Chain Reaction Receptors, Antigen, T-Cell, alpha-beta / analysis Receptors, Complement 3d / analysis T-Lymphocytes / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD20; 0/Receptors, Antigen, T-Cell, alpha-beta; 0/Receptors, Complement 3d |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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