Document Detail

In vivo transformation of neural stem cells following transplantation in the injured nervous system.
MedLine Citation:
PMID:  19834881     Owner:  NLM     Status:  MEDLINE    
Johnson et al report tumor formation following murine neural precursor cell transplantation in a rat peripheral nerve injury model, emphasizing the importance of full in vitro characterization of cells prior to transplantation. Cell lines can change during expansion and subclones which may become tumerogenic may be selected in the process of expansion. Cell transplantation studies with committed cells that have been minimally manipulated and expanded in culture such as olfactory ensheathing cells and Schwann cells may pose less risk of tumerogenicity, but have the disadvantage of limited cell harvest yields. The balance between in vitro transformation of expanded cell lines and the limitation of cell harvest yields from preparation of more stable committed cells must be considered in selection of cells for therapeutic intervention for nerve repair.
Christine Radtke; Joern Redeker; Andreas Jokuszies; Peter M Vogt
Publication Detail:
Type:  Comment; Letter     Date:  2009-10-15
Journal Detail:
Title:  Journal of reconstructive microsurgery     Volume:  26     ISSN:  1098-8947     ISO Abbreviation:  J Reconstr Microsurg     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-06-10     Revised Date:  2011-02-16    
Medline Journal Info:
Nlm Unique ID:  8502670     Medline TA:  J Reconstr Microsurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211-2     Citation Subset:  IM    
Copyright Information:
Copyright Thieme Medical Publishers.
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MeSH Terms
Cell Differentiation
Cell Line
Disease Models, Animal
Nerve Crush
Nerve Regeneration
Neuroblastoma / diagnosis,  etiology*,  pathology
Neurons / cytology,  physiology*
Peripheral Nervous System Neoplasms / diagnosis,  etiology*,  pathology
Risk Factors
Sciatic Nerve / injuries*
Stem Cell Transplantation* / adverse effects
Stem Cells / cytology*
Comment On:
J Reconstr Microsurg. 2008 Nov;24(8):545-50   [PMID:  18819061 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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